LXY3
Based on 1 Customer Validation
LXY3 (LXY2) is a VLA-3-blocking peptide that inhibits the interaction between integrin α3β1 (VLA-3) on neutrophil surfaces and laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is used to block neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. LXY3 is commonly employed for targeted imaging of breast cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.33%
- CAS. Nr.: 1095009-44-1
- Formel: C32H43N11O15S2
- Molecular Weight:885.88
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | IC50 |
7.4 μM
Compound: 1, LXY3, cdGTyr(3-NO2)GHypNc
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Binding affinity to alpha3beta1 integrin receptor in human MDA-MB-231 cells assessed as inhibition of cell binding to immobilized LXY1 peptide by cell adherence assay
Binding affinity to alpha3beta1 integrin receptor in human MDA-MB-231 cells assessed as inhibition of cell binding to immobilized LXY1 peptide by cell adherence assay
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[PMID: 19835381] |
Chemical Information
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CAS. Nr. 1095009-44-1
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Appearance Solid
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Molecular Weight 885.88
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Formel C32H43N11O15S2
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Color White to light yellow
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Synonyms
LXY2
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Sequence
{d-Cys}-{d-Asp}-Gly-{Tyr(3-NO2)}-Gly-{Hyp}-Asn-{d-Cys}-NH2 (disulfide bridge: d-Cys1-d-Cys8)
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Sequence Shortening
{d-Cys}-{d-Asp}-G-{Tyr(3-NO2)}-G-{Hyp}-N-{d-Cys}-NH2 (disulfide bridge: d-Cys1-d-Cys8)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (112.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (283 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Wang Q, et al. Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours. Nat Nanotechnol. 2024 Jan;19(1):95-105. [Content Brief]
[2]. Yao N. Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method. J Med Chem. 2009 Jan 8;52(1):126-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1288 mL | 5.6441 mL | 11.2882 mL | 28.2205 mL |
| 5 mM | 0.2258 mL | 1.1288 mL | 2.2576 mL | 5.6441 mL | |
| 10 mM | 0.1129 mL | 0.5644 mL | 1.1288 mL | 2.8221 mL | |
| 15 mM | 0.0753 mL | 0.3763 mL | 0.7525 mL | 1.8814 mL | |
| 20 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4110 mL | |
| 25 mM | 0.0452 mL | 0.2258 mL | 0.4515 mL | 1.1288 mL | |
| 30 mM | 0.0376 mL | 0.1881 mL | 0.3763 mL | 0.9407 mL | |
| 40 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7055 mL | |
| 50 mM | 0.0226 mL | 0.1129 mL | 0.2258 mL | 0.5644 mL | |
| 60 mM | 0.0188 mL | 0.0941 mL | 0.1881 mL | 0.4703 mL | |
| 80 mM | 0.0141 mL | 0.0706 mL | 0.1411 mL | 0.3528 mL | |
| 100 mM | 0.0113 mL | 0.0564 mL | 0.1129 mL | 0.2822 mL |
LXY3 Related Classifications
HY-P10934 Related Classifications
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