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Art. -Nr.: HY-117365

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MI-1481

MI-1481 is a highly potent inhibitor of the Menin-MLL1 interaction with IC₅₀ of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression.

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CAS. Nr.: 1887178-64-4
Formel: C₂₉H₃₀F₃N₇O₂S
Molecular Weight:597.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MI-1481 Chemical Structure

CAS. Nr.: 1887178-64-4

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Biologische Aktivität
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- Cellular Effect
Chemical Information
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Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
Bone marrow cell	GI₅₀	>6 μM Compound: (S)-28; MI-1481	Cytotoxicity against mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]
K562	GI₅₀	>6 μM Compound: (S)-28; MI-1481	Cytotoxicity against human K562 cells assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against human K562 cells assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]
MOLM-13	GI₅₀	61 nM Compound: (S)-28; MI-1481	Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]
MV4-11	GI₅₀	36 nM Compound: (S)-28; MI-1481	Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]
U-937	GI₅₀	>6 μM Compound: (S)-28; MI-1481	Cytotoxicity against human U937 cells assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against human U937 cells assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]

Chemical Information

CAS. Nr. 1887178-64-4
Molecular Weight 597.65
Formel C₂₉H₃₀F₃N₇O₂S
SMILES

N#CC(N1C[C@@H](OC2)CNC2=O)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Borkin D, et.al. Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. J Med Chem. 2018 Jun 14;61(11):4832-4850. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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MI-1481

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MI-1481 Related Classifications

HY-117365 Related Classifications