NSC 641396
NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity.
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- CAS. Nr.: 605685-94-7
- Formel: C18H13NO3
- Molecular Weight:291.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 605685-94-7
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Molecular Weight 291.30
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Formel C18H13NO3
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SMILES
O=C1C=CC(C2=C1C=CC3=C2N(C)C4=CC=C(OC)C=C34)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tholander F, et al. Discovery of antimicrobial ribonucleotide reductase inhibitors by screening in microwell format. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9798-803. [Content Brief]
[2]. Dong H, et al. Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nat Cancer. 2024 Apr;5(4):601-624. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NSC 641396 Related Classifications
HY-164497 Related Classifications
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