OUL312
Based on 1 Customer Validation
OUL312 is a potent PARP10 inhibitor (IC50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 (IC50 = 1500 nM). OUL312 is also at least 18-fold higher than all other human enzymes in the family. OUL312 has a good ADME profile, is able to enter cells, is not toxic, and effectively rescues human cells from PARP10-induced apoptosis at sub-micromolar concentrations. OUL312 can be used for the study of cervical cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.20%
- Formel: C16H13FN2O3
- Molecular Weight:300.28
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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PARP10 |
In Vitro
OUL312 (Compound 15) (0.05-10 μM, 10-12 days) shows no significant cytotoxicity in HeLa Flp-In TRex cells and could rescue Doxycycline (HY-N0565)-induced HeLa Flp-In TRex cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa Flp-In T-Rex cells
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Concentration:10 μM
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Incubation Time:10-12 days
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Result:Showed no significant cytotoxicity.
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Cell Line:Doxycycline-induced HeLa Flp-In T-Rex cells
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Concentration:0.05 μM, 0.1 μM, 0.5 μM, 1 μM, 10 μM
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Incubation Time:10-12 days
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Result:Rescued cells in a concentration-dependent manner with apparent EC50 below 1 μM.
Chemical Information
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Appearance Solid
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Molecular Weight 300.28
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Formel C16H13FN2O3
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Color White to off-white
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SMILES
O=C1NNC(C2=C1C=CC(OCCC3=CC=CC=C3F)=C2)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 10 mg/mL (33.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.3302 mL | 16.6511 mL | 33.3023 mL | 83.2556 mL |
| 5 mM | 0.6660 mL | 3.3302 mL | 6.6605 mL | 16.6511 mL | |
| 10 mM | 0.3330 mL | 1.6651 mL | 3.3302 mL | 8.3256 mL | |
| 15 mM | 0.2220 mL | 1.1101 mL | 2.2202 mL | 5.5504 mL | |
| 20 mM | 0.1665 mL | 0.8326 mL | 1.6651 mL | 4.1628 mL | |
| 25 mM | 0.1332 mL | 0.6660 mL | 1.3321 mL | 3.3302 mL | |
| 30 mM | 0.1110 mL | 0.5550 mL | 1.1101 mL | 2.7752 mL |
OUL312 Related Classifications
HY-178317 Related Classifications
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