Art. -Nr.: HY-N0314

Pectolinarin

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Pectolinarin possesses anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway.

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Reinheit: 99.89%
CAS. Nr.: 28978-02-1
Formel: C₂₉H₃₄O₁₅
Molecular Weight:622.57

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pectolinarin Chemical Structure

CAS. Nr.: 28978-02-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Pectolinarin possesses anti-inflammatory activity^[1]. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway^[2].

IC₅₀ & Target^[2]

IL-6

IL-8

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	32.9 μM Compound: 1	Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
A549	IC₅₀	38.8 μM Compound: 1	Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
ACHN	IC₅₀	17.2 μM Compound: 1	Antiproliferative activity against human ACHN cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human ACHN cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
ACHN	IC₅₀	17.22 μM Compound: Pectolinarin	In vitro inhibitory concentration against renal adenocarcinoma cell line (ACHN) in the presence of taxol In vitro inhibitory concentration against renal adenocarcinoma cell line (ACHN) in the presence of taxol	[PMID: 16125932]
C32	IC₅₀	7.2 μM Compound: 1	Antiproliferative activity against human C32 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human C32 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
Caco-2	IC₅₀	6.18 μM Compound: Pectolinarin	In vitro inhibitory concentration against human colorectal adenocarcinoma Caco-2 cells in the presence of vinblastine sulfate salt In vitro inhibitory concentration against human colorectal adenocarcinoma Caco-2 cells in the presence of vinblastine sulfate salt	[PMID: 16125932]
Caco-2	IC₅₀	6.2 μM Compound: 1	Antiproliferative activity against human Caco-2 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human Caco-2 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
COR-L23	IC₅₀	5 μM Compound: 1	Antiproliferative activity against human COR-L23 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human COR-L23 cells after 48 hrs by sulforhodamine B assay	[PMID: 18818071]
COR-L23	IC₅₀	5.03 μM Compound: Pectolinarin	In vitro inhibitory concentration against human carcinoma COR-L23 cells in the presence of vinblastine sulfate salt In vitro inhibitory concentration against human carcinoma COR-L23 cells in the presence of vinblastine sulfate salt	[PMID: 16125932]
HEK293	EC₅₀	>100 μM Compound: 18	Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay	[PMID: 24955889]
HepG2	IC₅₀	14.12 μM Compound: Pectolinarin	In vitro inhibitory concentration against human hepatocellular carcinoma HepG-2 cells in the presence of vinblastine sulfate salt In vitro inhibitory concentration against human hepatocellular carcinoma HepG-2 cells in the presence of vinblastine sulfate salt	[PMID: 16125932]
MRC5	IC₅₀	>80.3 μM Compound: Pectolinarin	In vitro inhibitory concentration against human fetal lung MRC-5 cell line in the presence of vinblastine sulfate salt In vitro inhibitory concentration against human fetal lung MRC-5 cell line in the presence of vinblastine sulfate salt	[PMID: 16125932]

In Vitro

Pectolinarin increases Bax level, and decreases Bcl-2 level in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). Pectolinarin inactivates the PI3K/Akt pathway in RA-FLSs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 28978-02-1
Appearance Solid
Molecular Weight 622.57
Formel C₂₉H₃₄O₁₅
Color Off-white to light yellow
SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]5[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)O4)O)O)O)=C(OC)C(O)=C13
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Monophenols
Initial Source
- Plants
- Compositae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

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Journal Impact Factor

Autophagy

XIAP-ULK1-Mediated mitophagy modulates carnitine metabolism to mitigate diabetic kidney disease. [Abstract]

2025 Oct 25. PMID: 41139215
Mol Neurobiol

Pectolinarin Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglia Polarization Through the PI3K/AKT Signaling Pathway. [Abstract]

2025 Jul;62(7):8587-8602. PMID: 40014266
J Cell Mol Med

Temperature-sensitive hydrogel releasing pectolinarin facilitate scarless wound healing. [Abstract]

2024 Feb;28(4):e18130. PMID: 38332511

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 31.25 mg/mL (50.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6062 mL

8.0312 mL

16.0625 mL

5 mM

0.3212 mL

1.6062 mL

3.2125 mL

10 mM

0.1606 mL

0.8031 mL

1.6062 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.08 mg/mL (3.34 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lim H, et al. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull. 2008 Nov;31(11):2063-7. [Content Brief]

[2]. Wang L, et al. Pectolinarin inhibits proliferation, induces apoptosis, and suppresses inflammation in rheumatoid arthritis fibroblast-like synoviocytes by inactivating the phosphatidylinositol 3 kinase/protein kinase B pathway.J Cell Biochem. 2019 Sep;120(9):15202-15210. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6062 mL	8.0312 mL	16.0625 mL	40.1561 mL
	5 mM	0.3212 mL	1.6062 mL	3.2125 mL	8.0312 mL
	10 mM	0.1606 mL	0.8031 mL	1.6062 mL	4.0156 mL
	15 mM	0.1071 mL	0.5354 mL	1.0708 mL	2.6771 mL
	20 mM	0.0803 mL	0.4016 mL	0.8031 mL	2.0078 mL
	25 mM	0.0642 mL	0.3212 mL	0.6425 mL	1.6062 mL
	30 mM	0.0535 mL	0.2677 mL	0.5354 mL	1.3385 mL
	40 mM	0.0402 mL	0.2008 mL	0.4016 mL	1.0039 mL
	50 mM	0.0321 mL	0.1606 mL	0.3212 mL	0.8031 mL

Keywords

Pectolinarin

3 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Pectolinarin

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Pectolinarin Related Classifications

HY-N0314 Related Classifications