DMPK
Encoded by the DMPK gene, whose 3'-UTR CTG-repeat expansion causes myotonic dystrophy type 1, DMPK is a muscle-enriched member of the AGC kinase family. Its architecture pairs a Ser/Thr kinase domain with an autoinhibitory alpha-helix and a C-terminal coiled-coil, Rho-binding region that targets the kinase to endoplasmic reticulum and mitochondrial outer membranes. Reported functions include regulation of L-type calcium and sodium channel behavior in muscle, myoblast differentiation, and cytoskeletal dynamics through phosphorylation of the phosphatase subunit MYPT1 and intermediate-filament proteins such as desmin. In DM1, the expanded-repeat mRNA sequesters MBNL proteins while DMPK protein levels are altered in patient muscle, connecting this kinase directly to disease pathology. Recombinant DMPK supports myotonic dystrophy research and kinase-panel screening.
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DMPK Recombinant Proteins (11)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
