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Art. -Nr.: HY-186265

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SD-24

SD-24 is a selective antagonist targeting CCR2 with a K_i of 1 nM, and exhibits significantly reduced binding affinity to CXCR1 and CCR6. SD-24 is applicable for inflammation and immune-related research.

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CAS. Nr.: 1237502-86-1
Formel: C₁₉H₁₂Cl₃NO₅S
Molecular Weight:472.73

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SD-24 Chemical Structure

CAS. Nr.: 1237502-86-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

CCR2

1 nM (Ki)

Alle CCR Isoform-spezifische Produkte anzeigen :

In Vitro

SD-24 (compound 15) (10 μM) shows no significant binding to the IABS of CXCR1_Nluc and CCR6_Nluc in HEK293T cell membranes at a concentration of 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1237502-86-1
Molecular Weight 472.73
Formel C₁₉H₁₂Cl₃NO₅S
SMILES

O=C(O)C1=CC=CC=C1OC2=C(NS(=O)(C3=CC(Cl)=C(Cl)C=C3)=O)C=C(Cl)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Huber ME, et al. Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1. ChemMedChem. 2024 Oct 16;19(20):e202400284. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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SD-24

Alle CCR Isoform-spezifische Produkte anzeigen