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Art. -Nr.: HY-187015

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SR-2555

(Synonyms: NSC 314055)

SR-2555 (NSC 314055) is a CYP2D6 inhibitor with an IC₅₀ of 1017 μM against human CYP2D6. SR-2555 inhibits the AMMC demethylase activity of recombinant CYP2D6; differentially enhances the sensitivity of hypoxic cells to the lethal effect of γ-rays; and exhibits cytotoxicity against hypoxic cells. SR-2555 can be used in cancer-related research.

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CAS. Nr.: 74141-74-5
Formel: C₉H₁₄N₄O₅
Molecular Weight:258.23

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR-2555 Chemical Structure

CAS. Nr.: 74141-74-5

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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

CYP2D6

1017 μM (IC₅₀)

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In Vitro

SR-2555 (NSC 314055) weakly inhibits recombinant CYP2D6-mediated AMMC demethylase activity, with an IC₅₀ of 1017 μM^[1].
SR-2555 exhibits radiosensitizing efficacy comparable to that of Misonidazole (HY-105061) in hypoxic Chinese hamster V79 cells^[2].
SR-2555 (2-5 mM; up to 8 hours) exhibits the lowest cytotoxicity among the tested 2-nitroimidazole compoundstoward hypoxic Chinese hamster V79 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 74141-74-5
Molecular Weight 258.23
Formel C₉H₁₄N₄O₅
SMILES

O=C(N(CCO)CCO)CN1C=CN=C1[N+]([O-])=O
Synonyms

NSC 314055
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kemp C A, et al. Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition. J. Med. Chem, 2004, 47(22): 5340-5346.

[2]. Astor M, et al. Newly synthesized hypoxia-mediated drugs as radiosensitizers and cytotoxic agents. International journal of radiation oncology, biology, physics. 1982 Jan;8(1):75-83. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SR-2555

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