VP3.15
Based on 3 publication(s) in Google Scholar
VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).
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- CAS. Nr.: 1281681-54-6
- Formel: C20H22N4OS
- Molecular Weight:366.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) VP3.15
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Biologische Aktivität
IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)[1]
Chemical Information
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CAS. Nr. 1281681-54-6
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Molecular Weight 366.48
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Formel C20H22N4OS
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SMILES
N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Biol Chem
REDD1-dependent GSK3β signaling in podocytes promotes canonical NF-κB activation in diabetic nephropathy. [Abstract]2025 Jan 27:108244. PMID: 39880090 -
J Biol Chem
REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice. [Abstract]2023 Aug;299(8):104991. PMID: 37392853 -
Reinheit & Dokumentation
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
VP3.15 Related Classifications
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