DAXX - death domain associated protein Gene

Also Known as DAP6; EAP1; BING2; SMIM40

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1616

About DAXX

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,318,558-33,322,959 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 189 orthologues and is associated with 83 phenotypes. Ubiquitous expression in testis (RPKM 26.2), lymph node (RPKM 25.5) and 25 other tissues.

Summary

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as Apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate Apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

DAXX Products (4)

mRNA	Protein	Name
NM_001141969.2	NP_001135441.1	death domain-associated protein 6 isoform a
NM_001141970.2	NP_001135442.1	death domain-associated protein 6 isoform b
NM_001254717.2	NP_001241646.1	death domain-associated protein 6 isoform c
NM_001350.5	NP_001341.1	death domain-associated protein 6 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	10698492	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16845383	GOA
enables histone binding	IDA IDA: Inferred from direct assay	12140263	GOA
enables molecular condensate scaffold activity	EXP EXP: Inferred from Experiment	30244836	GOA
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	15572661	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	16845383	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9215629	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10698492	GOA
enables protein kinase activator activity	IGI IGI: Inferred from genetic interaction	15983381	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15983381	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	15016915	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12140263	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	17081986	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	10698492	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16845383	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	9215629	GOA
involved in androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	15572661	GOA
involved in cellular response to cadmium ion	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to copper ion	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to diamide	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to sodium arsenite	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to unfolded protein	IDA IDA: Inferred from direct assay	15016915	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	20651253	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	9215629	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12140263	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	10698492	GOA
involved in neuron intrinsic apoptotic signaling pathway in response to oxidative stress	IGI IGI: Inferred from genetic interaction	15983381	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	20504901	GOA
involved in positive regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	15983381	GOA
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15878163	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	10698492	GOA
involved in regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	18566590	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	10669754	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	10504293	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	15572661	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15878163	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	10698492	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAXX Protein Structure

Daxx

0
200
400
600
740 a.a.

Protein Preferred Names	Protein Names
death domain-associated protein 6	CENP-C binding protein

DAXX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DAXX	Q9UER7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	25416956
Intra	DAXX	Q9UER7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	DAXX	Q9UER7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	25416956
Intra	DAXX	Q9UER7	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
Intra	DAXX	Q9UER7	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	DAXX	Q9UER7	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	DAXX	Q9UER7	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	DAXX	Q9UER7	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	DAXX	Q9UER7	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	DAXX	Q9UER7	CEP63	Homo sapiens	Q96MT8-3	Y2H Array	32296183
Intra	DAXX	Q9UER7	CEP63	Homo sapiens	Q96MT8-3	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Array	32296183
Intra	DAXX	Q9UER7	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	H3-3A	Homo sapiens	P84243	Anti Tag CoIP	33961781
Intra	DAXX	Q9UER7	H3-3A	Homo sapiens	P84243	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	H3-3A	Homo sapiens	P84243	Y2H Array	32296183
Intra	DAXX	Q9UER7	H3-3A	Homo sapiens	P84243	TAP	24981860
Intra	DAXX	Q9UER7	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
Intra	DAXX	Q9UER7	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	AIRE	Homo sapiens	O43918	Confocal	20185822
Intra	DAXX	Q9UER7	AIRE	Homo sapiens	O43918	Y2H	20185822
Intra	DAXX	Q9UER7	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	DAXX	Q9UER7	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	DAXX	Q9UER7	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	DAXX	Q9UER7	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	DAXX	Q9UER7	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	DAXX	Q9UER7	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	DAXX	Q9UER7	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Cross	DAXX	Q9UER7	Ripk3	Mus musculus	Q9QZL0	Pull Down	23260419
Intra	DAXX	Q9UER7	ZBTB2	Homo sapiens	Q8N680	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	ZBTB2	Homo sapiens	Q8N680	Y2H Array	32296183
Intra	DAXX	Q9UER7	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	DAXX	Q9UER7	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	DAXX	Q9UER7	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	RASSF3	Homo sapiens	Q86WH2	Y2H Array	32296183
Intra	DAXX	Q9UER7	RASSF3	Homo sapiens	Q86WH2	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	H3-5	Homo sapiens	Q6NXT2	Y2H Array	32296183
Intra	DAXX	Q9UER7	H3-5	Homo sapiens	Q6NXT2	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	Imaging	10669754
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	CoIP	10669754
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	Y2H	10669754
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	Anti Bait CoIP	12529400
Intra	DAXX	Q9UER7	PML	Homo sapiens	P29590	IF	14517282
Intra	DAXX	Q9UER7	TGFBR2	Homo sapiens	P37173	Y2H	11483955
Cross	DAXX	Q9UER7	Fas	Mus musculus	P25446	Y2H	9215629
Cross	DAXX	Q9UER7	Fas	Mus musculus	P25446	Pull Down	9215629
Cross	DAXX	Q9UER7	Pax5	Mus musculus	Q02650	Pull Down	11799127
Intra	DAXX	Q9UER7	HDAC2	Homo sapiens	Q92769	GMS	12140263
Intra	DAXX	Q9UER7	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	12529400
Intra	DAXX	Q9UER7	PNMA1	Homo sapiens	Q8ND90	BFG-2H	27107012
Intra	DAXX	Q9UER7	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	DAXX	Q9UER7	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	27107012
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Anti Tag CoIP	18566590
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Anti Bait CoIP	16845383
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Anti Bait CoIP	18566590
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Confocal	16845383
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	TAP	24981860
Intra	DAXX	Q9UER7	USP7	Homo sapiens	Q93009	Anti Tag CoIP	33961781
Intra	DAXX	Q9UER7	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	16810318
Intra	DAXX	Q9UER7	TSG101	Homo sapiens	Q99816	CoIP	15033475
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Y2H	11948183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Anti Tag CoIP	11948183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Pull Down	11948183
Intra	DAXX	Q9UER7	MCRS1	Homo sapiens	Q96EZ8	Anti Tag CoIP	22609355
Intra	DAXX	Q9UER7	HSPB1	Homo sapiens	P04792	PLA	25241761
Intra	DAXX	Q9UER7	HSPB1	Homo sapiens	P04792	Pull Down	11003656
Intra	DAXX	Q9UER7	RSL1D1	Homo sapiens	O76021	Crosslink	30021884
Intra	DAXX	Q9UER7	RSL1D1	Homo sapiens	O76021	Anti Tag CoIP	33961781
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	Anti Bait CoIP	16845383
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	IF	14557665
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	Anti Tag CoIP	15364927
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	IF	15364927
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	PLA	25241761
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	Anti Bait CoIP	15364927
Intra	DAXX	Q9UER7	TP53	Homo sapiens	P04637	Y2H	15364927
Intra	DAXX	Q9UER7	RASSF1	Homo sapiens	Q9NS23	Anti Tag CoIP	18566590
Intra	DAXX	Q9UER7	RASSF1	Homo sapiens	Q9NS23	Anti Bait CoIP	18566590
Intra	DAXX	Q9UER7	RASSF1	Homo sapiens	Q9NS23	IF	18566590
Intra	DAXX	Q9UER7	MKRN1	Homo sapiens	Q9UHC7	Validated Y2H	32296183
Intra	DAXX	Q9UER7	MKRN1	Homo sapiens	Q9UHC7	Y2H Array	32296183
Intra	DAXX	Q9UER7	MKRN1	Homo sapiens	Q9UHC7	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	18566590
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	16845383
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Pull Down	16845383
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	15364927
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Fluorescence	16845383
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	18583933
Intra	DAXX	Q9UER7	MDM2	Homo sapiens	Q00987	Display Tech	20195357
Intra	DAXX	Q9UER7	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	DAXX	Q9UER7	ZFAT	Homo sapiens	Q9P243	Anti Tag CoIP	36162510
Intra	DAXX	Q9UER7	ZFAT	Homo sapiens	Q9P243	Anti Bait CoIP	36162510
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	Anti Bait CoIP	24651726
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	Imaging	12953102
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	TAP	24981860
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	Anti Tag CoIP	26496610
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	CoIP	12953102
Intra	DAXX	Q9UER7	ATRX	Homo sapiens	P46100	Anti Tag CoIP	33961781
Intra	DAXX	Q9UER7	DMAP1	Homo sapiens	Q9NPF5	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	DMAP1	Homo sapiens	Q9NPF5	Y2H Array	32296183
Intra	DAXX	Q9UER7	RASSF1	Homo sapiens	Q9NS23-4	Imaging	16810318
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	Confocal	11495919
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	Pull Down	11003656
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	Anti Bait CoIP	11495919
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	CoIP	9743501
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	11495919
Intra	DAXX	Q9UER7	MAP3K5	Homo sapiens	Q99683	PLA	25241761
Intra	DAXX	Q9UER7	FAS	Homo sapiens	P25445	PLA	25241761
Intra	DAXX	Q9UER7	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	DAXX	Q9UER7	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	DAXX	Q9UER7	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	STAT3	Homo sapiens	P40763	Confocal	16331268
Intra	DAXX	Q9UER7	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	DAXX	Q9UER7	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	DAXX	Q9UER7	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	DAXX	Q9UER7	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	DAXX	Q9UER7	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
Intra	DAXX	Q9UER7	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	DAXX	Q9UER7	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	DAXX	Q9UER7	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	AR	Homo sapiens	P10275	Anti Bait CoIP	15572661
Intra	DAXX	Q9UER7	AR	Homo sapiens	P10275	Y2H	15572661
Intra	DAXX	Q9UER7	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	GOLGA2	Homo sapiens	Q08379	BFG-2H	27107012
Intra	DAXX	Q9UER7	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	DAXX	Q9UER7	GOLGA2	Homo sapiens	Q08379	Validated Y2H	27107012
Intra	DAXX	Q9UER7	CDKN2A	Homo sapiens	Q8N726	Anti Bait CoIP	18583933
Intra	DAXX	Q9UER7	CDKN2A	Homo sapiens	Q8N726	Y2H	18583933
Intra	DAXX	Q9UER7	CDKN2A	Homo sapiens	Q8N726	Confocal	18583933
Cross	DAXX	Q9UER7	Hipk1	Mus musculus	O88904	Anti Bait CoIP	12529400
Intra	DAXX	Q9UER7	FTH1	Homo sapiens	P02794	Y2H	21988832
Intra	DAXX	Q9UER7	FTH1	Homo sapiens	P02794	Y2H	21573799
Intra	DAXX	Q9UER7	FTH1	Homo sapiens	P02794	Anti Tag CoIP	21573799
Intra	DAXX	Q9UER7	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	DAXX	Q9UER7	RELA	Homo sapiens	Q04206	Confocal	17362989
Intra	DAXX	Q9UER7	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	DAXX	Q9UER7	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	KCTD4	Homo sapiens	Q8WVF5	Y2H Array	32296183
Intra	DAXX	Q9UER7	KCTD4	Homo sapiens	Q8WVF5	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	SPOP	Homo sapiens	O43791	Anti Tag CoIP	21988832
Intra	DAXX	Q9UER7	SPOP	Homo sapiens	O43791	Y2H	21573799
Intra	DAXX	Q9UER7	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	DAXX	Q9UER7	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	DAXX	Q9UER7	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	DAXX	Q9UER7	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	DAXX	Q9UER7	CARD9	Homo sapiens	Q9H257	Y2H Prey Pooling	25416956
Intra	DAXX	Q9UER7	CARD9	Homo sapiens	Q9H257	Y2H Array	25416956
Intra	DAXX	Q9UER7	MSANTD4	Homo sapiens	Q8NCY6	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	MSANTD4	Homo sapiens	Q8NCY6	Y2H Array	32296183
Intra	DAXX	Q9UER7	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	11112409
Intra	DAXX	Q9UER7	SUMO1	Homo sapiens	P63165	Anti Bait CoIP	23395904
Intra	DAXX	Q9UER7	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	23395904
Intra	DAXX	Q9UER7	UBE2I	Homo sapiens	P63279	Pull Down	23395904
Intra	DAXX	Q9UER7	CREBBP	Homo sapiens	Q92793	CoIP	11799127
Intra	DAXX	Q9UER7	USH1G	Homo sapiens	Q495M9	Y2H Prey Pooling	32296183
Intra	DAXX	Q9UER7	USH1G	Homo sapiens	Q495M9	Y2H Array	32296183
Intra	DAXX	Q9UER7	TCF7L2	Homo sapiens	Q9NQB0	Anti Tag CoIP	16569639
Intra	DAXX	Q9UER7	TCF7L2	Homo sapiens	Q9NQB0	IF	16569639
Intra	DAXX	Q9UER7	TCF7L2	Homo sapiens	Q9NQB0	Y2H	16569639
Cross	DAXX	Q9UER7	HSPB1	Cricetulus longicaudatus	P15991	Y2H	11003656
Cross	DAXX	Q9UER7	HSPB1	Cricetulus longicaudatus	P15991	Pull Down	11003656
Cross	DAXX	Q9UER7	E1B	Human adenovirus C	P03244	Y2H	14557665
Cross	DAXX	Q9UER7	E1B	Human adenovirus C	P03244	Anti Bait CoIP	14557665
Cross	DAXX	Q9UER7	e1b55_ade05	Human adenovirus C	P03243	IF	14557665
Cross	DAXX	Q9UER7	e1b55_ade05	Human adenovirus C	P03243	Anti Bait CoIP	14557665
Cross	DAXX	Q9UER7	mtp_ebvb9	Epstein-Barr virus	P03179	Anti Bait CoIP	22102817

Cross: Cross-species interaction Intra: Intraspecies interaction

DAXX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83109	Daxx Antibody (YA2854)	WB, ICC/IF	Human
HY-P83109A	Daxx Antibody (YA2854)(PBS only)	WB, ICC/IF	Human
HY-P84859	Daxx Antibody (YA4556)	WB, ICC/IF, FC, ELISA	Human
HY-P84859A	Daxx Antibody (YA4556)(PBS only)	WB, ICC/IF, FC, ELISA	Human
HY-P85118	Daxx Antibody (YA4810)	WB, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Gastric Neuroendocrine Neoplasm	Gastric Neuroendocrine Tumor Neuroendocrine Tumor Of The Stomach Neuroendocrine Tumor Of Stomach Gnet Gastric Net Net Of Stomach
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Alpha-Thalassemia Myelodysplasia Syndrome	ATMDS Acquired Hemoglobin H Disease Alpha-Thalassemia Myelodysplasia Syndrome, Somatic Acquired Hbh Disease Alpha-Thalassemia-Myelodysplastic Syndrome Hemoglobin H Disease, Acquired Acquired Alpha-Thalassemia With Myelodysplastic Syndrome Hemoglobin H Disease Acquired Thalassemia, Alpha, Myelodysplasia Syndrome, Somatic
Glottis Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Glottis Squamous Cell Carcinoma Of Glottis
Alpha Thalassemia-X-Linked Intellectual Disability Syndrome	Atr-X Syndrome Atr, Nondeletion Type Alpha-Thalassemia X-Linked Intellectual Disability Syndrome Atrx Syndrome Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome Xlmr Hypotonic Face Syndrome Alpha Thalassemia X-Linked Intellectual Disability Syndrome Alpha Thalassemia X-Linked Mental Retardation Syndrome Alpha Thalassemia/Mental Retardation, X-Linked Alpha-Thalassemia X-Linked Mental Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type X-Linked Alpha-Thalassemia/Mental Retardation Syndrome Xlmr-Hypotonic Face Syndrome Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked
Thalassemia	Sickle-Cell Thalassemia With Crisis Sickle-Cell Thalassemia Without Crisis Thalassemia Hb-S Disease With Crisis Thalassemia Hb-S Disease Without Crisis Thalassemias Hereditary Leptocytosis Haemoglobin Thalassaemia Disorder Thalassaemia Syndrome Thalassaemia Nos Thalassemia Variants
Pancreatic Endocrine Carcinoma	Carcinoma Of Endocrine Pancreas Islet Cell Carcinoma Malignant Neoplasm Of Islets Of Langerhans Pancreatic Neuroendocrine Carcinoma Carcinoma Islet Cell Carcinoma, Islet Cell
Alpha Thalassemia-Intellectual Disability Syndrome Type 1	Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16 Atr Syndrome Linked To Chromosome 16 Atr Syndrome, Deletion Type Atr-16 Syndrome Alpha Thalassemia-Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type Alpha-Thalassemia/Mental Retardation Syndrome, Type 1 Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
Islet Cell Tumor	Pancreatic Neuroendocrine Tumor Neuroendocrine Tumor Of Pancreas Pnet Pancreatic Net Pancreatic Endocrine Tumor Well-Differentiated Nen Of Pancreas Well-Differentiated Neuroendocrine Neoplasm Of Pancreas Well-Differentiated Pancreatic Nen Well-Differentiated Pancreatic Neuroendocrine Neoplasm Endocrine Pancreas Cancer Islet Cell Neoplasm Islet Cell Tumour Malignant Pancreatic Endocrine Tumor Malignant Pancreatic Endocrine Tumour Malignant Tumor Of Endocrine Pancreas Malignant Tumour Of Endocrine Pancreas Pancreatic Endocrine Neoplasm Pancreatic Neuroendocrine Neoplasm Adenoma, Islet Cell Well Differentiated Pancreatic Endocrine Tumor Malignant Neoplasm Of Endocrine Pancreas Pancreatic Endocrine Carcinoma
Cutis Laxa, Autosomal Dominant 1	Cutis Laxa, Autosomal Dominant Autosomal Dominant Cutis Laxa ADCL1 Adcl Autosomal Dominant Cutis Laxa 1 Cutis Laxa, Autosomal Dominant, 1 Cutis Laxa, Autosomal Dominant, Type 1
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03535	DAXX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19318	Daxx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25809	Daxx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DAXX	VGNC	VGNC:39777
Rattus norvegicus	DAXX	RGD	RGD:621227
Bos taurus	DAXX	VGNC	VGNC:27884
Macaca mulatta	DAXX	VGNC	VGNC:71737
Mus musculus	DAXX	MGD	MGI:1197015
Others	DAXX	NCBI