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Cat. No.: HY-144830

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6BrCaQ

6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates.

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CAS No.: 954416-67-2
Formule: C₁₈H₁₅BrN₂O₃
Masse moléculaire:387.23

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

6BrCaQ Chemical Structure

CAS No.: 954416-67-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	8 μM Compound: 6BrCaQ	Antiproliferative activity against human Caco2 cells assessed as inhibition of cell proliferation Antiproliferative activity against human Caco2 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
HT-29	IC₅₀	20 μM Compound: 6BrCaQ	Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34952432]
IGROV-1	IC₅₀	5 μM Compound: 6BrCaQ	Antiproliferative activity against human IGROV1 cells assessed as inhibition of cell proliferation Antiproliferative activity against human IGROV1 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
Ishikawa	IC₅₀	2 μM Compound: 6BrCaQ	Antiproliferative activity against human Ishikawa cells assessed as inhibition of cell proliferation Antiproliferative activity against human Ishikawa cells assessed as inhibition of cell proliferation	[PMID: 24992077]
LP-1	GI₅₀	6.2 μM Compound: 6BrCaQ	Growth inhibition of human LP-1 cells after 72 hrs by MTS assay Growth inhibition of human LP-1 cells after 72 hrs by MTS assay	[PMID: 24992077]
MCF7	GI₅₀	7 μM Compound: 6BrCaQ	Growth inhibition of ER-positive human MCF7 cells after 72 hrs by MTT assay Growth inhibition of ER-positive human MCF7 cells after 72 hrs by MTT assay	[PMID: 24992077]
MCF7	IC₅₀	7 μM Compound: 6BrCaQ	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
MCF7	IC₅₀	7 μM Compound: 6BrCaQ	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth	[PMID: 34952432]
MDA-MB-231	GI₅₀	0.06 μM Compound: 6BrCaQ	Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay	[PMID: 34952432]
MDA-MB-231	GI₅₀	2 μM Compound: 6BrCaQ	Growth inhibition of ER-negative human MDA-MB-231 cells after 72 hrs by MTT assay Growth inhibition of ER-negative human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 24992077]
MDA-MB-231	IC₅₀	2 μM Compound: 6BrCaQ	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
PC-3	GI₅₀	10 μM Compound: 6BrCaQ	Growth inhibition of human PC3 cells after 72 hrs by MTS assay Growth inhibition of human PC3 cells after 72 hrs by MTS assay	[PMID: 24992077]
RPMI-8226	GI₅₀	5 μM Compound: 6BrCaQ	Growth inhibition of human RPMI8226 cells after 72 hrs by MTS assay Growth inhibition of human RPMI8226 cells after 72 hrs by MTS assay	[PMID: 24992077]

Chemical Information

CAS No. 954416-67-2
Masse moléculaire 387.23
Formule C₁₈H₁₅BrN₂O₃
SMILES

COC1=CC=C(C=C1)C(NC2=CC3=CC(Br)=CC=C3N(C2=O)C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mathieu C, et, al. Synthesis and antiproliferative activity of 6BrCaQ-TPP conjugates for targeting the mitochondrial heat shock protein TRAP1. Eur J Med Chem. 2022 Feb 5;229:114052. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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