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Verteporfin

(Synonyms: CL 318952)
286 Cited Publications
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Based on 286 publication(s) in Google Scholar

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation.

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  • Pureté: 98.15%
  • CAS No.: 129497-78-5
  • Formule: C41H42N4O8
  • Masse moléculaire:718.79
  • Stockage:

    -20°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

  • Verteporfin Chemical Structure
    Verteporfin Chemical Structure
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
  • Experimental Validation Results for Verteporfin
CAS No.: 129497-78-5
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  • Verteporfin Chemical Structure
    Verteporfin Chemical Structure
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    Verteporfin purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Jan 13;15(1):202-226. [Abstract]

    Customer Validation
     Verteporfin (0.5 μM; pretreatment for 4 hours followed by 30-minute treatment) inhibits norepinephrine (NE)- or dexmedetomidine (DEX)-induced YAP dephosphorylation (activated state) in AKP tumor cells, restores phosphorylation levels of LATS1 and YAP, and blocks ADRA2A/Gi-mediated YAP signaling pathway activation.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Apr 1;21(1):238. [Abstract]

    Customer Validation
     Verteporfin (13.9 µM; 10 µg/mL; 24 h) decreases the expression of YAP and CDX2 in NSCCs.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Reprod Sci. 2023 Sep;30(9):2715-2727. [Abstract]

    Customer Validation
     Verteporfin (0-5 µM; 24 h) decreases the viability of Ishikawa cells in a concentration-dependent manner (IC50 = 1.345 µM).

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Reprod Sci. 2023 Sep;30(9):2715-2727. [Abstract]

    Customer Validation
     Verteporfin (0.5, 1, 2 µM) decreases the expression of anti-apoptotic marker B cell leukemia 2 (Bcl2), while increases the expression of pro-apoptotic protein Bcl2-associated X protein (Bax) in Ishikawa cells, in a concentration-dependent manner.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Jun;32(6):543-554. [Abstract]

    Customer Validation
     Survival of mice with striatal GL261 tumor injection with or without RT, saline plus laser treatment, or Verteporfin (Visudyne; 2 mg/mL; 5 μL was injected into the cisterna magna; 15 min) plus laser treatment.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2022 Jul;25(7):849-864. [Abstract]

    Customer Validation
     Verteporfin (1 µM)-treated animals exposed to 640 nm in the head exhibits less mrc1a+ cells in the brain compared to non-photoactivated control animals.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Oct 5;13(1):5871. [Abstract]

    Customer Validation
     Mice are injected with either Verteporfin (VP; 100 mg/kg) or vehicle (corn oil) from the postnatal 7 days at 3-day intervals for 14 days. The immunohistochemical assay shows that the expression of TFRC and COX2 is higher in Bnc1tr/tr control mouse ovaries than in Bnc1+/+ control mouse ovaries. Intriguingly, VP treatment partially rescues TFRC and COX2 expression in Bnc1tr/tr mouse ovaries.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Verteporfin displays a complete suppression of viral CPE at 0.31 µM. Viral N protein expression in infected Vero E6 cells was assessed by immunofluorescence.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Protoporphyrin IX and Verteporfin effectively prevent SARS-CoV-2 infection in the mouse model expressing human ACE2. Much fewer cells expressed viral N protein in the Protoporphyrin IX and Verteporfin (20 µM) groups compared to the DMSO group.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Verteporfin (0.31 µM) inhibits N protein expression in SARS-CoV-2-infected Vero E6 cells.​

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Antiviral effect and cell cytotoxicity of protoporphyrin IX and verteporfin. The viral RNA production in the supernatant of infected Vero E6 cells was quantified with qRT-PCR. The value at each compound concentration was presented relative to that at zero compound concentration that was set as 100% (blue).

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153. [Abstract]

    Customer Validation
     The expression levels of Hippo-YAP signaling downstream regenerative genes (Ctgf, Ankrd1 and Cyr61) are effectively inhibited by Verteporfin (VP; 100 µM) compared to their expression in the blank control group.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153. [Abstract]

    Customer Validation
     Compared to cell viability in the vehicle control group, Verteporfin (VP; 100 µM) markedly impairs cell viability assayed by JC-1 staining and CCK-8.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153. [Abstract]

    Customer Validation
     Compared to cell viability in the vehicle control group, Verteporfin (VP; 100 µM) markedly impairs cell viability assayed by JC-1 staining and CCK-8.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153. [Abstract]

    Customer Validation
     The protective effects of TNIP3 against cell inflammation and cell death were largely abolished by Verteporfin (VP; 100 µM) administration.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cell Res. 2020 Mar;30(3):229-243. [Abstract]

    Customer Validation
     The representative images of dCLNs and sCLNs 2 weeks after striatal injection of GL261 or B16 cells into mice treated with Vehicle + Laser or =Verteporfin (Visudyne; 2 mg/mL; 5 μL was injected into the cisterna magna; 15 min) + Laser.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2019 Sep 16;36(3):302-318.e7. [Abstract]

    Customer Validation
     Combined treatment of GFAP-Ptch tumor cells with Verteporfin (VP; 24 hours) and CD532 additively decreases proliferation of ZIC1+ tumor cells relative to individual treatments.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2019 Jan 3;73(1):7-21.e7. [Abstract]

    Customer Validation
     Control low metastatic MDA-MB-231 cells or cells overexpressing OTUB2-WT, pretreated with or without Verteporfin (VP, 10 µM) are intracardially injected into nude mice.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Immunol. 2019 Mar:107:29-40. [Abstract]

    Customer Validation
     Col1a1 and α-SMA protein levels are analyzed in cells treated with VP.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Immunol. 2019 Mar:107:29-40. [Abstract]

    Customer Validation
     Col1a1 and α-SMA protein levels are analyzed in cells treated with VP.

  • 1/16

    Verteporfin purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2018 Dec 11:12:489. [Abstract]

    Customer Validation
     OECs are treated with vehicle (0.1% DMSO), Y27632 (10 μM) or verteporfin (5 μM) for 24 h and performed WB analysis.

  • Verteporfin