Aklavin
Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene.
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- CAS No.: 60504-57-6
- Formule: C30H35NO10
- Masse moléculaire:569.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Aklavin (0.001-5.0 mg/mL) shows variable phagocidal activity against free phage particles, with paratyphoid Poona phage 1 being the most sensitive (99% inactivation at 0.05 mg/mL) and Bacillus cereus phage being the least sensitive (33% inactivation at 5.0 mg/mL), and requires far higher concentrations to inactivate free phages than to prevent phage-mediated lysis[2].
Aklavin (24 h; 72 h) inhibits bacterial growth with varying potency via agar dilution assay, showing the highest potency against Corynebacterium sepedonicum (minimum inhibitory concentration 1.56 μg/mL after 72 hr incubation) and the lowest potency against 7 bacterial species (minimum inhibitory concentration >100 μg/mL after 24 hr incubation)[2].
Aklavin hydrochloride (0.1-10 nM; 5 days) does not alter the SMN2 splicing pattern in SV40-transformed type I SMA fibroblast cell line 3061[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SV40-transformed type I SMA fibroblast cell line 3061
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Concentration:0.1 nM, 1 nM, 10 nM
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Incubation Time:5 days
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Result:Failed to alter the SMN2 splicing pattern.
Remained comparable to untreated or DMSO-treated cells in full-length SMN transcript levels and the ratio of full-length to Δexon 7 isoforms.
Aklavin (0.002-0.05 mg/kg; i.p.) does not inhibit herpetic infection in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with Eastern equine encephalomyelitis[2]
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Dosage:0.002 mg/mL, 0.01 mg/mL, 0.1 mg/mL, 1.0 mg/mL
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Administration:injection; post 1-hour pre-incubation with virus
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Result:Protected all six mice from 0.1% virus when dosed at 0.01 mg/mL, 0.1 mg/mL, or 1.0 mg/mL.
Resulted in 1 survivor out of six mice from 0.1% virus when dosed at 0.002 mg/mL.
Protected all six mice from 1% virus when dosed at 1.0 mg/mL.
Resulted in 1 survivor out of six mice from 1% virus when dosed at 0.1 mg/mL.
Resulted in 3 survivors out of six mice from 1% virus when dosed at 0.01 mg/mL.
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Animal Model:Mice with Herpetic infection[2]
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Dosage:0.002 mg/kg, 0.05 mg/kg
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Administration:i.p.
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Result:Showed no effect on herpetic infection in mice at 0.002 mg/kg dose.
Showed no effect on herpetic infection in mice at 0.05 mg/kg dose.
Chemical Information
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CAS No. 60504-57-6
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Masse moléculaire 569.60
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Formule C30H35NO10
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SMILES
COC([C@@H]1C2=C(C(O)=C3C(C(C4=CC=CC(O)=C4C3=O)=O)=C2)[C@H](C[C@]1(O)CC)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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