Cat. No.: HY-N3017

Artemitin

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Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED₅₀ of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED₅₀ of 1.6 μg/kg, and has analgesic activity.

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Pureté: 99.97%
CAS No.: 479-90-3
Formule: C₂₀H₂₀O₈
Masse moléculaire:388.37

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Artemitin Chemical Structure

CAS No.: 479-90-3

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Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	2200 ng/mL Compound: 10	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 11975496]
HepG2	IC₅₀	229 μM Compound: Artemetin	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 31784199]
HL-60	IC₅₀	6.44 μM Compound: VIII, 5-demethylhexaMF	Antiproliferative activity against HL60 after 24 hrs Antiproliferative activity against HL60 after 24 hrs	[PMID: 17391969]
Neutrophil	IC₅₀	>10 μg/mL Compound: 9	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release using Meo-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 5 mins prior to FMLP/CB-challenge by spectrophotometry Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release using Meo-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 5 mins prior to FMLP/CB-challenge by spectrophotometry	[PMID: 22429052]
Neutrophil	IC₅₀	>10 μg/mL Compound: 9	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide-anion generation incubated for 5 mins prior to FMLP/CB-challenge measured after 10 mins by spectrophotometry Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide-anion generation incubated for 5 mins prior to FMLP/CB-challenge measured after 10 mins by spectrophotometry	[PMID: 22429052]
PC-12	GI₅₀	2270 ng/mL Compound: 10	Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 11975496]
SH-SY5Y	IC₅₀	229 μM Compound: Artemetin	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 31784199]

In Vitro

Artemitin (10 μg/mL; 48 h) shows moderate cytotoxicity against Meth-A sarcoma cells with an ED₅₀ of 5-10 μg/mL, without significant cytotoxicity against LLC lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Meth-A sarcoma cells, LLC lung carcinoma cells
Concentration:

5-10 μg/mL
Incubation Time:

48 h
Result:

Dose-dependent growth inhibition against Meth-A cells, with ED₅₀ values ranging from 5 to 10 μg/ml, while no significant cytotoxic effects were observed in LLC cells under the same conditions.

In Vivo

The peak concentration of Artemitin (10 mg/kg; tail vein injection; single dose; monitoring 0.08-6 h after administration) in the plasma of male SD rats is 0.08 h after administration (C_max=487.6 μg/L)^[2].
Artemitin (1.6 μg/kg; ip; single dose; observation 60 min after administration) significantly prolongs the latency of pain response in the hot plate model of male mice, showing a dose-dependent antinociceptive effect^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pharmacokinetic study in Male SD rats (150-200 g)^[2]
Dosage:

10 mg/kg
Administration:

Tail vein injection, single dose, blood samples collected at 0.08, 0.17, 0.33, 0.5, 0.75, 1, 2, 3, 4, and 6 h post-administration
Result:

After a single intravenous dose of 10 mg/kg, Artemitin rapidly distributed in rats with C_max achieved at 0.08 h (487.6 μg/L).
The pharmacokinetic parameters were calculated using a two-compartment model, including AUC_(0-t)=862.403 μg/L·h, AUC_(0-∞)=929.84 μg/L·h), and T_1/2=1.556 h, indicating rapid elimination with measurable plasma concentrations up to 6 h.

Chemical Information

CAS No. 479-90-3
Appearance Solid
Masse moléculaire 388.37
Formule C₂₀H₂₀O₈
Color White to yellow
SMILES

O=C1C2=C(O)C(OC)=C(OC)C=C2OC(C3=CC(OC)=C(OC)C=C3)=C1OC
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Monophenols
Initial Source
- Plants
- other families
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (128.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5749 mL

12.8743 mL

25.7486 mL

5 mM

0.5150 mL

2.5749 mL

5.1497 mL

10 mM

0.2575 mL

1.2874 mL

2.5749 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ma CM, et al. Triterpenes and lignans from Artemisia caruifolia and their cytotoxic effects on meth-A and LLC tumor cell lines. Chem Pharm Bull (Tokyo). 2001 Feb;49(2):183-7. [Content Brief]

[2]. Han X, et al. Development of an LC-MS/MS-based assay to determine artemitin in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2018 Dec;32(12):e4356. [Content Brief]

[3]. Qnais, Esam, et al. Antinociceptive effect of two flavonoids from Aloysia triphylla L. Jordan Journal of Biological Sciences 2.4 (2009): 167-170.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5749 mL	12.8743 mL	25.7486 mL	64.3716 mL
	5 mM	0.5150 mL	2.5749 mL	5.1497 mL	12.8743 mL
	10 mM	0.2575 mL	1.2874 mL	2.5749 mL	6.4372 mL
	15 mM	0.1717 mL	0.8583 mL	1.7166 mL	4.2914 mL
	20 mM	0.1287 mL	0.6437 mL	1.2874 mL	3.2186 mL
	25 mM	0.1030 mL	0.5150 mL	1.0299 mL	2.5749 mL
	30 mM	0.0858 mL	0.4291 mL	0.8583 mL	2.1457 mL
	40 mM	0.0644 mL	0.3219 mL	0.6437 mL	1.6093 mL
	50 mM	0.0515 mL	0.2575 mL	0.5150 mL	1.2874 mL
	60 mM	0.0429 mL	0.2146 mL	0.4291 mL	1.0729 mL
	80 mM	0.0322 mL	0.1609 mL	0.3219 mL	0.8046 mL
	100 mM	0.0257 mL	0.1287 mL	0.2575 mL	0.6437 mL

Keywords

Artemitin

1 Cited Publications

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Artemitin

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Publications Citing Use of MedChemExpress (MCE) Artemitin

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Artemitin Related Classifications

HY-N3017 Related Classifications