BMS-952048
BMS-952048 is a positive allosteric modulator of mGluR5 with an EC50 of 10 nM.
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- CAS No.: 1375751-32-8
- Formule: C21H13F2N3O2
- Masse moléculaire:377.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>3000 nM
Compound: 22; BMS-952048
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Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay
Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay
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[PMID: 27496211] |
| HEK293 | EC50 |
10 nM
Compound: 22; BMS-952048
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Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay
Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay
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[PMID: 27496211] |
Chemical Information
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CAS No. 1375751-32-8
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Masse moléculaire 377.34
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Formule C21H13F2N3O2
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SMILES
O=C1O[C@H](C2=CC=C(F)C=C2)[C@@H](C3=CC(C#CC4=NC=CC=C4F)=CN=C3)N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-952048 Related Classifications
HY-123874 Related Classifications
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