C-Reactive Protein (CRP) (174-185)
Based on 1 Customer Validation
C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of caspase-3/9 through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma.
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- Pureté : 99.88%
- CAS No.: 147516-85-6
- Formule: C62H93N13O16
- Masse moléculaire:1276.48
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Stockage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
C-Reactive Protein (CRP) (0-25 μg/mL; 24 h) promotes monocyte migration by stimulating 3T3-L1 adipocytes to produce CXCL7[3]. C-Reactive Protein (CRP) can impair G1/S-dependent regeneration of renal tubular epithelial cells[4]. C-Reactive Protein (CRP) (10 μg/mL, 4 days) can enhance TSCC cell viability and increase cell resistance to DDP[5]. C-Reactive Protein (CRP) is a highly structurally conserved major acute phase plasma protein in humans[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A murine model of pneumococcal infection[1].
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Dosage:25 μg
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Administration:Intravenous injection (i.v.); once daily; 7 days
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Result:Activated complement in mouse serum.
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Animal Model:Male hooded Wistar rats (weighing 125-150 g)[2].
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection (i.p.); once daily; 3 days
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Result:Upregulated PKC, NADPH oxidase, ERK, and JNK phosphorylation.
Chemical Information
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CAS No. 147516-85-6
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Appearance Solid
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Masse moléculaire 1276.48
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Formule C62H93N13O16
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Color White to off-white
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Sequence
Ile-Tyr-Leu-Gly-Gly-Pro-Phe-Ser-Pro-Asn-Val-Leu
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Sequence Shortening
IYLGGPFSPNVL
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvant et solubilité
In Vitro:
H2O : 10 mg/mL (7.83 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Singh SK, et al. Complement Activation by C-Reactive Protein Is Critical for Protection of Mice Against Pneumococcal Infection. Front Immunol. 2020 Aug 13;11:1812. [Content Brief]
[2]. Devaraj S, et al. C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo. Atherosclerosis. 2009 Mar;203(1):67-74. [Content Brief]
[3]. Chen JY, et al. C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia. J Transl Med. 2020 Feb 11;18(1):68. [Content Brief]
[4]. Tang Y, et al. C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration. Clin Sci (Lond). 2014 May;126(9):645-59. [Content Brief]
[5]. Yan X, et al. C-reactive protein promotes tongue squamous cell carcinoma chemoresistance by inhibiting the activation of caspase-3/9 via the CD64/AKT/mTOR pathway. Hum Cell. 2021 Sep;34(5):1424-1433. [Content Brief]
[6]. Ansar W, et al. C-reactive protein and the biology of disease. Immunol Res. 2013 May;56(1):131-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.7834 mL | 3.9170 mL | 7.8340 mL | 19.5851 mL |
| 5 mM | 0.1567 mL | 0.7834 mL | 1.5668 mL | 3.9170 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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