Concanamycin B
Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type H+-ATPases, and the IC50 value is 5 nM.
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- CAS No.: 81552-33-2
- Formule: C44H71NO14
- Masse moléculaire:838.03
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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Macrolide |
In Vitro
Concanamycin B (5-25 nM, 1h) inhibits the accumulation of lipid droplets and cholesterol esters in macrophages J774 induced by oxidized low-density lipoprotein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 81552-33-2
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Masse moléculaire 838.03
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Formule C44H71NO14
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SMILES
O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)OC(N)=O)O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C1/O
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Synonyms
MCH 210
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Structure Classification
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Initial Source
Streptomyces sp
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
[1]. Yilla M, et al. Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. J Biol Chem. 1993 Sep 5;268(25):19092-100. PMID: 8395529. [Content Brief]
[2]. Woo JT, et al. Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774. Eur J Biochem. 1992 Jul 1;207(1):383-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Concanamycin B Related Classifications
HY-125707 Related Classifications
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