Cat. No.: HY-N2573

Corydalmine

(Synonyms: L-Corydalmine; TLZ-16)

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Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

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Pureté: 99.74%
CAS No.: 30413-84-4
Formule: C₂₀H₂₃NO₄
Masse moléculaire:341.40

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Corydalmine Chemical Structure

CAS No.: 30413-84-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi^[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity^[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway^[3].

IC₅₀ & Target^[3]

CXCR2

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.19 μM Compound: 18k	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	[PMID: 23332346]
HEK293	EC₅₀	1.35 μM Compound: 18k	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	[PMID: 23332346]
HEK293	IC₅₀	18.73 μM Compound: 18k	Antagonist activity at dopamine D2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay Antagonist activity at dopamine D2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	[PMID: 23332346]
HEK293	IC₅₀	21.27 μM Compound: 18k	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	[PMID: 23332346]
THP-1	IC₅₀	152.43 nM Compound: 6	Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs	[PMID: 23199480]

In Vivo

Corydalmine (L-Corydalmine) is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 30413-84-4
Appearance Solid
Masse moléculaire 341.40
Formule C₂₀H₂₃NO₄
Color Off-white to light yellow
SMILES

OC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC
Synonyms

L-Corydalmine; TLZ-16
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Phenols
- Monophenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 30 mg/mL (87.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9291 mL

14.6456 mL

29.2912 mL

5 mM

0.5858 mL

2.9291 mL

5.8582 mL

10 mM

0.2929 mL

1.4646 mL

2.9291 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From Corydalis Chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71. [Content Brief]

[2]. Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105. [Content Brief]

[3]. Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9291 mL	14.6456 mL	29.2912 mL	73.2279 mL
	5 mM	0.5858 mL	2.9291 mL	5.8582 mL	14.6456 mL
	10 mM	0.2929 mL	1.4646 mL	2.9291 mL	7.3228 mL
	15 mM	0.1953 mL	0.9764 mL	1.9527 mL	4.8819 mL
	20 mM	0.1465 mL	0.7323 mL	1.4646 mL	3.6614 mL
	25 mM	0.1172 mL	0.5858 mL	1.1716 mL	2.9291 mL
	30 mM	0.0976 mL	0.4882 mL	0.9764 mL	2.4409 mL
	40 mM	0.0732 mL	0.3661 mL	0.7323 mL	1.8307 mL
	50 mM	0.0586 mL	0.2929 mL	0.5858 mL	1.4646 mL
	60 mM	0.0488 mL	0.2441 mL	0.4882 mL	1.2205 mL
	80 mM	0.0366 mL	0.1831 mL	0.3661 mL	0.9153 mL

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Corydalmine

Anti-Infection Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Small Molecule Immuno-Oncology Compound Library

Antifungal Compound Library

Medicine Food Homology Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Alkaloids Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Chemokine Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Cytokine Inhibitors Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Anti-Rheumatic Arthritis Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform CXCR

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Corydalmine Related Classifications

Cat. No.: HY-N2573