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Cat. No.: HY-122641A

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Deltasonamide 2

1 Cited Publications

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Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a K_d of ~385 pM.

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CAS No.: 2088485-34-9
Formule: C₃₀H₃₉ClN₆O₄S₂
Masse moléculaire:647.25

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Data Sheet (267 KB)

Deltasonamide 2 Chemical Structure

CAS No.: 2088485-34-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a K_d of ~385 pM^[1].

IC₅₀ & Target

Kd: ~385 pM (PDEδ)^[1]

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	1.2 μM Compound: Deltasonamide 2	Antiproliferative activity against human AGS cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay Antiproliferative activity against human AGS cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay	[PMID: 34965125]
MIA PaCa-2	IC₅₀	507 nM Compound: Deltasonamide 2	Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay	[PMID: 34965125]
NCI-H358	IC₅₀	954 nM Compound: Deltasonamide 2	Antiproliferative activity against human NCI-H358 cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay Antiproliferative activity against human NCI-H358 cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay	[PMID: 34965125]
PaTu 8988t	IC₅₀	1.2 μM Compound: Deltasonamide 2	Antiproliferative activity against human PaTu 8988t cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay Antiproliferative activity against human PaTu 8988t cells assessed as reduction in cell viability measured after 3 days by Celltiter-Glo assay	[PMID: 34965125]

Chemical Information

CAS No. 2088485-34-9
Appearance Solid
Masse moléculaire 647.25
Formule C₃₀H₃₉ClN₆O₄S₂
Color White to off-white
SMILES

O=S(C1=CC=C(S(=O)(N(CC2=CC=C(Cl)C=C2)C3CCCC3)=O)C=C1)(N([C@H]4CC[C@H](N)CC4)CC5=NC(NC)=NC=C5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Med Chem

Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. [Abstract]

2022 Jan 13;65(1):747-756. PMID: 34965125

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Klein CH, et al. PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell linesharboring oncogenic KRas. Int J Cancer. 2019 Feb 15;144(4):767-776. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Deltasonamide 2

1 Cited Publications

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Chemical Information
Publications (1)
Pureté et documentation
Références

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Deltasonamide 2

Publications Citing Use of MedChemExpress (MCE) Deltasonamide 2

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE)

Activité biologique

Chemical Information

Publications (1)

Pureté et documentation

Références

Calculators

Help & FAQs

Deltasonamide 2 Related Classifications

HY-122641A Related Classifications