NFKBIA - NFKB inhibitor alpha Gene
Also Known as IKBA; MAD-3; NFKBI; EDAID2
Species: Homo sapiens
About NFKBIA
This gene has 21 transcripts (splice variants), 81 orthologues, 4 paralogues and is associated with 5 phenotypes. Broad expression in bone marrow (RPKM 430.4), ovary (RPKM 112.0) and 21 other tissues.
Summary
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
NFKBIA Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_020529.3 | NP_065390.1 | NF-kappa-B inhibitor alpha |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables NF-kappaB binding |
IDA
IDA: Inferred from direct assay
|
7628694 | GOA |
| enables NF-kappaB binding |
IPI
IPI: Inferred from physical interaction
|
7739562 | GOA |
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
16648481 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
16951195 | GOA |
| enables molecular sequestering activity |
IDA
IDA: Inferred from direct assay
|
7479976 | GOA |
| enables nuclear localization sequence binding |
IPI
IPI: Inferred from physical interaction
|
1493333 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9452483 | GOA |
| enables protein sequestering activity |
IDA
IDA: Inferred from direct assay
|
1493333 | GOA |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
9859996 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| is active in cytoplasm |
IDA
IDA: Inferred from direct assay
|
1493333 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
3140380 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
7679069 | GOA |
NFKBIA Protein Structure
Ank_2: Ankyrin repeats (3 copies) (78 - 167)
Ank_2: Ankyrin repeats (3 copies) (181 - 245)
- 0
- 100
- 200
- 300
- 317 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
NF-kappa-B inhibitor alpha |
|
NFKBIA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
NFKBIA | P25963 | NEDD9 | Homo sapiens | Q14511-2 | 32296183 | |
|
Intra
|
NFKBIA | P25963 | POM121 | Homo sapiens | Q96HA1-2 | 32296183 | |
|
Intra
|
NFKBIA | P25963 | COMMD1 | Homo sapiens | Q8N668 | 14685242 | |
|
Intra
|
NFKBIA | P25963 | COMMD1 | Homo sapiens | Q8N668 | 14685242 | |
|
Intra
|
NFKBIA | P25963 | NEDD9 | Homo sapiens | Q14511 | 25416956 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206-2 | 14743216 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206-2 | 28514442 | |
|
Intra
|
NFKBIA | P25963 | NFKB1 | Homo sapiens | P19838 | 9865693 | |
|
Intra
|
NFKBIA | P25963 | NFKB1 | Homo sapiens | P19838 | 26496610 | |
|
Intra
|
NFKBIA | P25963 | NFKB1 | Homo sapiens | P19838 | 17003112 | |
|
Intra
|
NFKBIA | P25963 | NFKB1 | Homo sapiens | P19838 | 17003112 | |
|
Intra
|
NFKBIA | P25963 | NFKB1 | Homo sapiens | P19838 | 33961781 | |
|
Intra
|
NFKBIA | P25963 | NFKB2 | Homo sapiens | Q00653 | 33961781 | |
|
Intra
|
NFKBIA | P25963 | NFKB2 | Homo sapiens | Q00653 | 28514442 | |
|
Intra
|
NFKBIA | P25963 | NFKB2 | Homo sapiens | Q00653 | 14743216 | |
|
Intra
|
NFKBIA | P25963 | REL | Homo sapiens | Q04864 | 33961781 | |
|
Intra
|
NFKBIA | P25963 | REL | Homo sapiens | Q04864 | 26496610 | |
|
Intra
|
NFKBIA | P25963 | REL | Homo sapiens | Q04864 | 28514442 | |
|
Intra
|
NFKBIA | P25963 | REL | Homo sapiens | Q04864 | 14743216 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 24634218 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 14685242 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 21988832 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 17003112 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 26496610 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 23850221 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 23563313 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 21217772 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 16951195 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 17301240 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 24457201 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 17003112 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 9865693 | |
|
Intra
|
NFKBIA | P25963 | RELA | Homo sapiens | Q04206 | 33961781 | |
|
Intra
|
NFKBIA | P25963 | RPS3 | Homo sapiens | P23396 | 24457201 | |
|
Intra
|
NFKBIA | P25963 | RPS3 | Homo sapiens | P23396 | 24457201 | |
|
Intra
|
NFKBIA | P25963 | NFKBIB | Homo sapiens | Q15653 | 33961781 | |
|
Intra
|
NFKBIA | P25963 | FBXW11 | Homo sapiens | Q9UKB1 | 33961781 | |
|
Intra
|
NFKBIA | P25963 | FBXW11 | Homo sapiens | Q9UKB1 | 12482991 | |
|
Intra
|
NFKBIA | P25963 | GRK2 | Homo sapiens | P25098 | 19008357 | |
|
Intra
|
NFKBIA | P25963 | GRK2 | Homo sapiens | P25098 | 19008357 | |
|
Cross
|
NFKBIA | P25963 | Chuk | Mus musculus | Q60680-2 | 10733566 | |
|
Intra
|
NFKBIA | P25963 | GRK5 | Homo sapiens | P34947 | 19008357 | |
|
Intra
|
NFKBIA | P25963 | GRK5 | Homo sapiens | P34947 | 19008357 | |
|
Intra
|
NFKBIA | P25963 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
NFKBIA | P25963 | HIF1AN | Homo sapiens | Q9NWT6 | 33961781 | |
|
Intra
|
NFKBIA | P25963 | HIF1AN | Homo sapiens | Q9NWT6 | 28514442 | |
|
Intra
|
NFKBIA | P25963 | TCL1A | Homo sapiens | P56279 | 32296183 | |
|
Cross
|
NFKBIA | P25963 | UL54 | Human herpesvirus 1 | Q9J0X9 | 18539148 | |
|
Cross
|
NFKBIA | P25963 | UL54 | Human herpesvirus 1 | Q9J0X9 | 18539148 | |
|
Intra
|
NFKBIA | P25963 | CHUK | Homo sapiens | O15111 | 10733566 | |
|
Intra
|
NFKBIA | P25963 | CHUK | Homo sapiens | O15111 | 12486103 | |
|
Intra
|
NFKBIA | P25963 | CHUK | Homo sapiens | O15111 | 18922877 | |
|
Intra
|
NFKBIA | P25963 | CHUK | Homo sapiens | O15111 | 33961781 | |
|
Intra
|
NFKBIA | P25963 | CHUK | Homo sapiens | O15111 | 28514442 | |
|
Intra
|
NFKBIA | P25963 | IKBKB | Homo sapiens | O14920 | 21423167 | |
|
Intra
|
NFKBIA | P25963 | IKBKB | Homo sapiens | O14920 | 21423167 | |
|
Intra
|
NFKBIA | P25963 | IKBKB | Homo sapiens | O14920 | 19196987 | |
|
Intra
|
NFKBIA | P25963 | IKBKB | Homo sapiens | O14920 | 16286467 | |
|
Intra
|
NFKBIA | P25963 | IKBKG | Homo sapiens | Q9Y6K9 | 26496610 | |
|
Cross
|
NFKBIA | P25963 | polg_den2n | Dengue virus type 2 | P14340 | 24973451 | |
|
Cross
|
NFKBIA | P25963 | P14340-PRO_0000037965 | Dengue virus type 2 | P14340-PRO_0000037965 | 24973451 | |
|
Cross
|
NFKBIA | P25963 | P14340-PRO_0000037965 | Dengue virus type 2 | P14340-PRO_0000037965 | 24973451 |
Recombinant NFKBIA Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P74841 | IkB alpha Protein, Human (His) | P25963/NP_065390.1 (F2-L317) | ≥ 90%, as determined by reducing SDS-PAGE. |
NFKBIA Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P80466 | Phospho-IKB alpha (Ser32) Antibody (YA183) | WB, ICC/IF, IP | Human, Mouse |
| HY-P80466A | Phospho-IKB alpha (Ser32) Antibody (YA183) (PBS only) | WB, ICC/IF, IP | Human, Mouse |
| HY-P80718 | IKB alpha Antibody (YA350) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P80718A | IKB alpha Antibody (YA350)(PBS only) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P80826 | Phospho-IKB alpha (Ser32) Antibody (YA185) | WB, IP | Human, Mouse |
| HY-P80826A | Phospho-IKB alpha (Ser32) Antibody (YA185)(PBS only) | WB, IP | Human, Mouse |
| HY-P80827 | Phospho-IKB alpha (Ser36) Antibody (YA184) | WB | Human, Mouse |
| HY-P80827A | Phospho-IKB alpha (Ser36) Antibody (YA184)(PBS only) | WB | Human, Mouse |
| HY-P86197 | IκB-α Antibody (YA5889) | WB, IHC-P, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86746 | IKB alpha Antibody (YA6438) | WB, IHC-P, IHC-F, IF-Tissue, ICC/IF | Human, Rat |
| HY-P86746A | IKB alpha Antibody (YA6438)(PBS only) | WB, IHC-P, IHC-F, IF-Tissue, ICC/IF | Human, Rat |
| HY-P87026 | Phospho-IKB alpha (S36) Antibody (YA6719) | WB | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ectodermal Dysplasia And Immunodeficiency 2 |
|
|
| Hypohidrotic Ectodermal Dysplasia With Immunodeficiency |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Ectodermal Dysplasia |
|
|
| Gliosarcoma |
|
|
| Giant Cell Glioblastoma |
|
|
| Covid-19 |
|
|
| Newcastle Disease |
|
|
| Psoriatic Arthritis |
|
|
| Burkitt Lymphoma |
|
|
| Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive |
|
|
| B-Cell Lymphoma |
|
|
| Lung Cancer |
|
|
| Colorectal Cancer |
|
|
| Carbuncle |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Rheumatoid Arthritis |
|
|
| Pancreatic Cancer |
|
|
| Prostate Cancer |
|
|
| Human Immunodeficiency Virus Type 1 |
|
|
| Lymphoma, Hodgkin, Classic |
|
|
| Intellectual Developmental Disorder, X-Linked 108 |
|
|
| Myelodysplastic Syndrome |
|
|
| Immune Deficiency Disease |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Nephrotic Syndrome |
|
|
| Systemic Lupus Erythematosus |
|
|
| Multiple Sclerosis |
|
|
| Cardiomyopathy, Dilated, 1gg |
|
|
| Asthma |
|
|
| Diabetes Mellitus |
|
|
| Hepatocellular Carcinoma |
|
|
| Gastric Cancer |
|
|
| Myeloma, Multiple |
|
|
| Ovarian Cancer |
|
|
| Glycogen Storage Disease Iv |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations |
|
|
| Night Blindness, Congenital Stationary, Type 1h |
|
|
| Breast Cancer |
|
|
| Mantle Cell Lymphoma |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Connective Tissue Disease |
|
|
| Skin Disease |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | NFKBIA | VGNC | VGNC:32045 |
| Felis catus | NFKBIA | VGNC | VGNC:68483 |
| Mus musculus | NFKBIA | MGD | MGI:104741 |
| Canis familiaris | NFKBIA | VGNC | VGNC:43782 |
| Macaca mulatta | NFKBIA | VGNC | VGNC:75340 |
| Rattus norvegicus | NFKBIA | RGD | RGD:3171 |
| Others | NFKBIA | NCBI |