Gentamicin C2
Gentamicin C2 is an aminoglycoside antibiotic with broad-spectrum bactericidal activity, selectively binding to the bacterial 16S rRNA A-site. Gentamicin C2 interferes with protein synthesis initiation and translation fidelity to exert bactericidal effects. Gentamicin C2 can be used for the research of bacterial infections.
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- CAS No.: 25876-11-3
- Formule: C20H41N5O7
- Masse moléculaire:463.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
| Species | Dose | Route | AUC0-∞ | CL | Vss | MRT | T1/2 |
|---|---|---|---|---|---|---|---|
| Dog[2] | 2 mg/kg | i.v. | 41820 μg·h/mL | 1.82 mL/min/kg | 0.15 L/kg | 84 min | 66 min |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Beagle (4 males, 2 females, 16-20 kg)[2]
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Dosage:1.984 mg/kg
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Administration:i.v.; single bolus
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Result:Achieved a mean area under the plasma concentration-time curve (AUC) of 697 μg·mL-1·min.
Reached a total body clearance (CL) of 1.82 mL·min-1·kg-1.
Attained a volume of distribution at steady state (Vss) of 0.15 liter/kg.
Had a mean residence time (MRT) of 84 min.
Exhibited a terminal half-life (t1/2) of 66 min.
Showed an elimination rate constant (β) of 0.011 min-1.
Reached a volume of distribution in the elimination phase (Vβ) of 0.17 liter/kg.
Demonstrated statistically significant differences in CL, Vss, and Vβ compared to Gentamicin C1 (P = 0.0156).
Showed no statistically significant differences in any parameters compared to Gentamicin C1a.
Had no differences in MRT and t1/2 compared to Gentamicin C1 and Gentamicin C1a.
Chemical Information
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CAS No. 25876-11-3
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Masse moléculaire 463.57
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Formule C20H41N5O7
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SMILES
O[C@@H]([C@@H]1O[C@H]([C@@H](CC2)N)O[C@]2([H])[C@H](N)C)[C@H]([C@@H](C[C@@H]1N)N)O[C@@H](OC[C@@]3(O)C)[C@@H]([C@H]3NC)O
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Structure Classification
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Initial Source
Micromonospora spp
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gu Y, et al. Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex. Chembiochem. 2015;16(13):1933-1942. [Content Brief]
[2]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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