JTE-607
Based on 6 publication(s) in Google Scholar
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607.
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- Pureté: 98.64%
- CAS No.: 188791-09-5
- Formule: C25H33Cl4N3O5
- Masse moléculaire:597.36
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Publications Citing Use of MedChemExpress (MCE) JTE-607
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Customer Validation & Images
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Flow Cytometry
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Flow Cytometry
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In Vivo Efficacy Study
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IHC
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IHC
Activité biologique
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IL-10 |
IL-6 |
IL-8 |
JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. The inhibitory effects of JTE-607 are also seen in mRNA expression of those cytokines[1].
JTE-607 inhibits inflammatory cytokine production from LPS-stimulated human PBMCs with an IC50 of approximately 10 nM[1].
JTE607 inhibits LPS-stimulated IL-8 production from monkey and rabbit PBMCs, and TNF-α production from mouse and rat PBMCs with IC50s of 59, 780, 1600 and 19000 nM, respectively[1].
JTE607 also suppresses other cytokines, granulocyte-macrophage colony stimulating factor and IL-1RA with IC50s of 2.4±0.8 and 5.4±0.4 nM, respectively[1].
JTE-607 inhibits cytokine production in monkey, rabbit, mouse and rat with IC50s of 59±26, 780±120, 1600±650 and 19000±3200 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human peripheral blood mononuclear cells (PBMCs)
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Concentration:100 nM
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Incubation Time:20 hours
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Result:Reduced the increase in the level of mRNAs of TNF-α, IL-1b, IL-6 and IL-8.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (5 to 6 weeks old) are sensitized by injecting Corynebacterium parvum[1]
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Dosage:0.3, 1, 3, 10 mg/kg
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Administration:Administered intravenously 10 min before the LPS challenge.
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Result:Showed dose dependent inhibition of the mortality at 0.3 to 10 mg/kg and significant effect at 3 and 10 mg/kg.
Chemical Information
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CAS No. 188791-09-5
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Appearance Solid
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Masse moléculaire 597.36
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Formule C25H33Cl4N3O5
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Color White to off-white
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SMILES
CCOC([C@H](CC1=CC=CC=C1)NC(C2=C(C(Cl)=C(C(Cl)=C2)OCCN3CCN(CC3)C)O)=O)=O.Cl.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Cell Discov
RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation. [Abstract]2024 Mar 19;10(1):32. PMID: 38503731
JTE-607 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]
JTE-607 (7.143 μg per day per mouse; ICV) NSG immunocompromised mice suppressed tumor growth and prolonged mouse survival.
JTE-607 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]
JTE-607 (7.143 μg per day per mouse; ICV) in NSG immunocompromised mice suppressed tumor growth and prolonged mouse survival.
JTE-607 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32. [Abstract]
JTE-607 (7.143 μg per day per mouse; ICV) in NSG immunocompromised mice induced tumor cell apoptosis, as measured by the TUNEL assay.
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Nucleic Acids Res
2026 Jan 22;54(3):gkaf1487. PMID: 41569153
JTE-607 purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 22;54(3):gkaf1487. [Abstract]
Flow cytometry analysis of HeLa cells without (-) or with the indicated concentrations of JTE-607 (500 nM) and adavosertib (AZD1775) for 24 h. Numbers indicate γH2AX-positive cells.
JTE-607 purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 22;54(3):gkaf1487. [Abstract]
Flow cytometry analysis of pRNAPII S2 levels on chromatin in HeLa cells without (-) or with 1 μM JTE-607 for 2, 6, and 24 h (orange color).
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Acta Pharm Sin B
DeepICER: A deep learning framework for predicting compound-induced gene expression profiles. [Abstract]2026 May;16(5):2947-2963. PMID: 42180546 -
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Cancer Lett
CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression. [Abstract]2024 Jul 1:593:216925. PMID: 38718887 -
Cell Rep
CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells. [Abstract]2025 Jan 22;44(1):115211. PMID: 39847481
Solvant et solubilité
DMSO : 250 mg/mL (418.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 20 mg/mL (33.48 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (167.40 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
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- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. M Kakutani, et al. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm Res. 1999 Aug;48(8):461-8. [Content Brief]
[2]. Nathan T Ross, et al. CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma. Nat Chem Biol. 2020 Jan;16(1):50-59. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.6740 mL | 8.3702 mL | 16.7403 mL | 41.8508 mL |
| 5 mM | 0.3348 mL | 1.6740 mL | 3.3481 mL | 8.3702 mL | |
| 10 mM | 0.1674 mL | 0.8370 mL | 1.6740 mL | 4.1851 mL | |
| 15 mM | 0.1116 mL | 0.5580 mL | 1.1160 mL | 2.7901 mL | |
| 20 mM | 0.0837 mL | 0.4185 mL | 0.8370 mL | 2.0925 mL | |
| 25 mM | 0.0670 mL | 0.3348 mL | 0.6696 mL | 1.6740 mL | |
| 30 mM | 0.0558 mL | 0.2790 mL | 0.5580 mL | 1.3950 mL | |
| DMSO | 40 mM | 0.0419 mL | 0.2093 mL | 0.4185 mL | 1.0463 mL |
| 50 mM | 0.0335 mL | 0.1674 mL | 0.3348 mL | 0.8370 mL | |
| 60 mM | 0.0279 mL | 0.1395 mL | 0.2790 mL | 0.6975 mL | |
| 80 mM | 0.0209 mL | 0.1046 mL | 0.2093 mL | 0.5231 mL | |
| 100 mM | 0.0167 mL | 0.0837 mL | 0.1674 mL | 0.4185 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
JTE-607 Related Classifications
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