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Cat. No.: HY-153685

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NISC-6

NISC-6 is a novel dual Topo-IIα/Akt inhibitor. NISC-6 has inhibitory activity against various cells, such as UACC903 (IC₅₀ = 2.5 µM) and CHL-1 (IC₅₀ = 0.8 µM) cells. NISC-6 dose dependently induces early and late apoptosis. NISC-6 can be used for research on melanoma.

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CAS No.: 2097636-49-0
Formule: C₁₉H₁₈N₂O₂Se
Masse moléculaire:385.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

NISC-6 Chemical Structure

CAS No.: 2097636-49-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Cellular Effect
Chemical Information
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Topoisomerase :

Voir tous les produits spécifiques à Isoform Akt :

Cellular Effect

Cell Line	Type	Value	Description	References
CHL-1	IC₅₀	0.8 μM Compound: 4d; NISC-6	Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 72 hrs by MTT assay Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 72 hrs by MTT assay	[PMID: 28458134]
CHL-1	IC₅₀	1.5 μM Compound: 4d; NISC-6	Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 48 hrs by MTT assay Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 48 hrs by MTT assay	[PMID: 28458134]
CHL-1	IC₅₀	13.7 μM Compound: 4d; NISC-6	Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 24 hrs by MTT assay Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 24 hrs by MTT assay	[PMID: 28458134]
UACC-903	IC₅₀	1.7 μM Compound: 4d; NISC-6	Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 72 hrs by MTT assay Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 72 hrs by MTT assay	[PMID: 28458134]
UACC-903	IC₅₀	13.4 μM Compound: 4d; NISC-6	Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 24 hrs by MTT assay Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 24 hrs by MTT assay	[PMID: 28458134]
UACC-903	IC₅₀	2.5 μM Compound: 4d; NISC-6	Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 48 hrs by MTT assay Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 48 hrs by MTT assay	[PMID: 28458134]

Chemical Information

CAS No. 2097636-49-0
Masse moléculaire 385.32
Formule C₁₉H₁₈N₂O₂Se
SMILES

O=C1C2=C3C(C(N1CCCCCCN=C=[Se])=O)=CC=CC3=CC=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Karelia DN, et al. Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity. Eur J Med Chem. 2017 Jul 28;135:282-295. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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NISC-6

Voir tous les produits spécifiques à Isoform Topoisomerase

Voir tous les produits spécifiques à Isoform Akt