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Cat. No.: HY-12641A

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Pyrantel

1 Cited Publications

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Pyrantel is an orally active antiparasitic agent. Pyrantel induces spastic paralysis in parasites via actions on neural and muscular cholinergic receptors as a nicotinic acetylcholine receptor (nAChR) agonist. Pyrantel eliminates both immature and mature endoparasites in horses. Pyrantel can be used in research related to parasitic infections.

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CAS No.: 15686-83-6
Formule: C₁₁H₁₄N₂S
Masse moléculaire:206.31

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Pyrantel Chemical Structure

CAS No.: 15686-83-6

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Description

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In Vitro

Pyrantel acts as an L-subtype cholinergic receptor agonist in Ascaris suum body-flap muscle, with a pEC₅₀ of 7.24^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pyrantel (10-30 mg of base/kg; administered orally via gastric tube; single dose) exhibits highly effective and stable anthelmintic activity against equine gastrointestinal nematodes (with a 100% clearance rate for immature Parascaris equorum, 99-100% for Strongylus vulgaris, and 92-95% for small strongyles), while its anthelmintic efficacy against Strongylus edentatus and immature Oxyuris equi varies^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 15686-83-6
Masse moléculaire 206.31
Formule C₁₁H₁₄N₂S
SMILES

CN1CCCN=C1/C=C/C2=CC=CS2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Eur J Med Chem

Innovative medicinal chemistry strategies for enhancing drug solubility. [Abstract]

2024 Dec 5:279:116842. PMID: 39260319

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (290 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Tritten L, et al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS neglected tropical diseases. 2011 Dec;5(12):e1457. [Content Brief]

[2]. Martin RJ, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. International journal for parasitology. 2004 Aug;34(9):1083-90. [Content Brief]

[3]. Lyons ET, et al. Critical test of three salts of pyrantel against internal parasites of the horse. Am J Vet Res. 1974 Dec;35(12):1515-22.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Pyrantel

1 Cited Publications

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Pyrantel

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Voir tous les produits spécifiques à Isoform Parasite

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