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Cat. No.: HY-N1338

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Royleanone

(Synonyms: NSC 122417)

Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells.

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CAS No.: 6812-87-9
Formule: C₂₀H₂₈O₃
Masse moléculaire:316.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Royleanone Chemical Structure

CAS No.: 6812-87-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

mTOR/PI3/AKT^[1]

Voir tous les produits spécifiques à Isoform mTOR :

Voir tous les produits spécifiques à Isoform Akt :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	30.14 μM Compound: 20	Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
BXPC-3	GI₅₀	51.04 μM Compound: 20	Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	GI₅₀	36.33 μM Compound: 20	Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	IC₅₀	>30 μM Compound: 3	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 23865778]
MCF7	IC₅₀	>30 μM Compound: 3	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23865778]
MIA PaCa-2	IC₅₀	32.5 μM Compound: 3	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay	[PMID: 21775156]
MOLT-3	IC₅₀	13.6 μM Compound: 3	Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay	[PMID: 23865778]
MRC5	GI₅₀	45.7 μM Compound: 20	Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PANC-1	GI₅₀	52.55 μM Compound: 20	Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PC-3	GI₅₀	27.07 μM Compound: 20	Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
SK-MEL-1	IC₅₀	>30 μM Compound: 3	Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay	[PMID: 23865778]
U-937	IC₅₀	>30 μM Compound: 3	Cytotoxicity against human U937 cells after 72 hrs by MTT assay Cytotoxicity against human U937 cells after 72 hrs by MTT assay	[PMID: 23865778]

In Vitro

Royleanone (0-200 μM; 48 h) inhibits the viability of LNCaP cancer cells in a dose-dependent manner, with an IC₅₀ of 12.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6812-87-9
Masse moléculaire 316.43
Formule C₂₀H₂₈O₃
SMILES

O=C1C(C(C)C)=C(O)C(C2=C1CC[C@@]3([H])C(C)(C)CCC[C@]23C)=O
Synonyms

NSC 122417
Structure Classification
- Quinones
- Anthraquinones
Initial Source
- Plants
- Labiatae
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Royleanone

Voir tous les produits spécifiques à Isoform mTOR

Voir tous les produits spécifiques à Isoform Akt

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Royleanone Related Classifications

HY-N1338 Related Classifications