TFSeB
TFSeB is an orally active neuroprotective agent. TFSeB can reduce Streptozotocin (STZ) (HY-13753) induced MAO-B and AChE activity. TFSeB exerts neuroprotective effects by increasing the expression of BCL-2, BDNF, NRF2, and decreasing the expression of BAX. TFSeB can reduce lipid peroxidation (TBARS) and reactive oxygen species (ROS) levels. TFSeB can reduce neuroinflammation. TFSeB can be used for research on Alzheimer’s disease.
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- CAS No.: 3017240-62-6
- Formule: C16H13F3OSe
- Masse moléculaire:357.23
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Bcl-2 |
AChE |
Bax |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss mice (25-35 g) received intracerebroventricular injections of Streptozotocin (STZ) (HY-13753) (3 mg/kg)[1]
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Dosage:1 mg/kg or 5 mg/kg
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Administration:Oral gavage (i.g.); once daily for 20 days
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Result:Significantly improved STZ-induced spatial working memory deficits.
Restored short-term and long-term recognition memory in the mice with an Alzheimer’s disease.
Significantly reduced MAO-B activity as a MAO-B modulator.
Significantly reversed AChE activity in the STZ mice.
Improved oxidative stress levels, including a reduction in TBARS, ROS, NOx, and NPSH levels.
Upregulated the levels of BDNF, NRF2 and BCL-2 and downregulated the levels of NF-κB, IL-6, CAT, SOD, GSk3B and BAX.
Did not cause liver, kidney toxicity or metabolic abnormalities.
Chemical Information
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CAS No. 3017240-62-6
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Masse moléculaire 357.23
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Formule C16H13F3OSe
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SMILES
FC(F)(C1=CC=CC([Se]CC2CC3=C(O2)C=CC=C3)=C1)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TFSeB Related Classifications
HY-174419 Related Classifications
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