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Cat. No.: HY-125230

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CN427

CN427 is a quinazoline-based BRD4 inhibitor with a K_d of 66 nM for BRD4. CN427 is applicable to the research of leukemia.

For research use only. We do not sell to patients.

CAS No.: 2260887-54-3
Formula: C₂₈H₂₈N₆O₃
Molecular Weight:496.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CN427 Chemical Structure

CAS No.: 2260887-54-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

CN427 is a quinazoline-based BRD4 inhibitor with a K_d of 66 nM for BRD4. CN427 is applicable to the research of leukemia^[1].

IC₅₀ & Target^[1]

BRD4

66 nM (Kd)

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Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	1.1 μM Compound: 65; CN427	Cytotoxicity against human MV411 cells after 72 hrs by CellTiter-Glo assay Cytotoxicity against human MV411 cells after 72 hrs by CellTiter-Glo assay	[PMID: 30268702]
MV4-11	IC₅₀	1.1 μM Compound: 8	Cytotoxicity against human MV4-11 cells assessed as inhibition of cell viability Cytotoxicity against human MV4-11 cells assessed as inhibition of cell viability	[PMID: 30905542]

In Vitro

CN427 inhibits MV4-11 cell viability with an IC₅₀ of 1.10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-∞	Bioavailability	V_ss	CL_plasma
Mice^[1]	2 mg/kg	i.v.	3.1 h	1690 ng/mL	1757 ng·h/mL	/	1.7 L/kg	19.8 mL/min/kg
Mice^[1]	10 mg/kg	p.o.	2.1 h	934 ng/mL	4494 ng·h/mL	51 %	/	/

Chemical Information

CAS No. 2260887-54-3
Molecular Weight 496.57
Formula C₂₈H₂₈N₆O₃
SMILES

OCCN1N=CC(=C1)C2=NC=3C=CC(=CC3C(=N2)N4CCOCC4C=5C=CC=CC5)C=6C(=NOC6C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang SM, et al. Discovery and lead identification of quinazoline-based BRD4 inhibitors. Bioorg Med Chem Lett. 2018;28(21):3483-3488. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CN427

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Biological Activity

Chemical Information

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CN427 Related Classifications

HY-125230 Related Classifications