CYP51-IN-36
CYP51-IN-36 is a CYP51 inhibitor and Antifungal agent. CYP51-IN-36 inhibits Ergosterol (HY-N0181) biosynthesis, induces intracellular ROS accumulation, disrupts mitochondrial function and causes mitochondrial membrane potential depolarization, impairs nuclear integrity, increases plasma membrane permeability and leads to electrolyte leakage, and inhibits SOD and POD antioxidant defense enzyme activities. CYP51-IN-36 exhibits antifungal activity against Botrytis cinerea, Rhizoctonia solani, Valsa mali and Sclerotinia sclerotiorum, and shows protective and disease control activity against Botrytis cinerea.
For research use only. We do not sell to patients.
- CAS No.: 3059617-75-0
- Formula: C12H10ClN3O2
- Molecular Weight:263.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CYP51 |
In Vitro
CYP51-IN-36 (100-200 μg/mL) provides high protective and curative activity against B. cinerea on potted tomato leaves, reaching 93.8% and 91.9% efficacy at 200 μg/mL[1].
CYP51-IN-36 (0.34 μg/mL) damages B. cinerea hyphal morphology and ultrastructure[1].
CYP51-IN-36 (50 μg/mL) damages the B. cinerea plasma membrane barrier and increases membrane permeability[1].
CYP51-IN-36 (25 μg/mL) strongly inhibits ergosterol biosynthesis in B. cinerea, with 91.74% inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3059617-75-0
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Molecular Weight 263.68
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Formula C12H10ClN3O2
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SMILES
O=C(C1=NC=CN1C)O/N=C/C2=CC=C(Cl)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYP51-IN-36 Related Classifications
HY-191408 Related Classifications
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Keywords
- CYP51-IN-36
- 3059617-75-0
- Fungal
- Cytochrome P450
- Reactive Oxygen Species (ROS)
- Mitochondrial Metabolism
- SOD
- CYPs
- Superoxide Dismutase
- Botrytis cinerea
- CYP51
- POD
- ergosterol biosynthesis
- mitochondrial function
- mitochondrial membrane potential
- plasma membrane permeability
- reactive oxygen species
- sterol 14α-demethylase
- Inhibitor
- inhibitor
- inhibit