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Conatumumab

(Synonyms: AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody)
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Based on 1 Customer Validation

Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. .

For research use only. We do not sell to patients.

  • Purity : 98.90%
  • CAS No.: 896731-82-1
  • Molecular Weight:145.44 kDa
  • Storage:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Conatumumab
  • Experimental Validation Results for Conatumumab
  • Experimental Validation Results for Conatumumab
  • Conatumumab Chemical Structure
    Conatumumab Chemical Structure
CAS No.: 896731-82-1
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Conatumumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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All TNF Receptor Isoforms

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1.5X106 HEPG2 cells with Conatumumab (HY-P99260, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control.

  • 1/16

    Immobilized HY-P7307 TRAIL R2/TNFRSF10B Protein, Human (HEK293) can bind Conatumumab. The EC50 for this effect is 2.37 ng/mL.

  • Conatumumab Chemical Structure
    1/16
  • Conatumumab
  • Flow cytometric analysis of 1.5X106 HEPG2 cells with Conatumumab (HY-P99260, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control.
  • Immobilized HY-P7307 TRAIL R2/TNFRSF10B Protein, Human (HEK293) can bind Conatumumab. The EC50 for this effect is 2.37 ng/mL.