BI-9321
BI-9321, a chemical probe, is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.
For research use only. We do not sell to patients.
- CAS No.: 2387510-86-1
- Formula: C22H21FN4
- Molecular Weight:360.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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NSD3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
0.139 μM
Compound: 18; BI-9321
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Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition measured after 6 days in presence of JQ1 by RealTime-Glow MT cell viability assay
Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition measured after 6 days in presence of JQ1 by RealTime-Glow MT cell viability assay
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[PMID: 37182335] |
| MOLM-13 | IC50 |
26.8 μM
Compound: 18; BI-9321
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Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition measured after 6 days by RealTime-Glow MT cell viability assay
Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition measured after 6 days by RealTime-Glow MT cell viability assay
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[PMID: 37182335] |
| MOLM-13 | IC50 |
26.8 μM
Compound: 39; BI-9321
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Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 38805937] |
| MOLM-13 | IC50 |
26.8 μM
Compound: BI-9321
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Inhibition of cell proliferation of human MOLM-13 cells incubated for 6 days by Real-time Glow MT assay
Inhibition of cell proliferation of human MOLM-13 cells incubated for 6 days by Real-time Glow MT assay
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[PMID: 38412693] |
BI-9321 is targeting the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 μM. As a single agent, BI-9321 downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2387510-86-1
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Molecular Weight 360.43
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Formula C22H21FN4
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SMILES
NCC1=CC(C)=C(C2=C(C3=CC=NC4=CC(F)=CC=C34)N(C)C=N2)C(C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BI-9321 Related Classifications
HY-114208 Related Classifications
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