SDS - serine dehydratase Gene

Also Known as SDH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10993

About SDS

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:113,392,445-113,403,887 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 5 paralogues. Biased expression in liver (RPKM 130.0) and brain (RPKM 4.0).

Summary

This gene encodes one of three Enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]

SDS Products (1)

mRNA Protein Name
NM_006843.3 NP_006834.2 L-serine dehydratase/L-threonine deaminase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-serine ammonia-lyase activity IDA
IDA: Inferred from direct assay
15618015 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
15689518 GOA
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
15689518 GOA
enables pyridoxal phosphate binding IMP
IMP: Inferred from mutant phenotype
16580895 GOA
enables threonine deaminase activity IDA
IDA: Inferred from direct assay
15618015 GOA
Biological Process GO Annotation Evidence References Source
involved in L-serine catabolic process IDA
IDA: Inferred from direct assay
15689518 GOA
involved in pyruvate biosynthetic process IDA
IDA: Inferred from direct assay
15689518 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDS Protein Structure

PALP

PALP: Pyridoxal-phosphate dependent enzyme (9 - 304)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

L-serine dehydratase/L-threonine deaminase

  • L-serine ammonia-lyase

SDS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SDS P20132 TGM7 Homo sapiens Q96PF1
Validated Y2H
32296183
Intra
SDS P20132 DDI1 Homo sapiens Q8WTU0
Validated Y2H
32296183
Intra
SDS P20132 DDI1 Homo sapiens Q8WTU0
Y2H Prey Pooling
32296183
Intra
SDS P20132 DDI1 Homo sapiens Q8WTU0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Abscess

  • Abscess Of Breast
Atrial Septal Defect 1

  • ASD1

  • Atrial Heart Septal Defect 1

  • Asd
Schizophrenia 1

  • SCZD1

  • Schizophrenia Susceptibility Locus, Chromosome 5-Related

  • Schizophrenia 1 With Or Without An Affective Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108717 Proteinase K / Unkown
HY-D0014 Brilliant blue G-250 ≥95.0% Unkown
HY-D0232 Brilliant Blue R250 ≥95.0% Unkown
HY-D0006 Bathophenanthroline 99.59% Unkown
HY-108717B Proteinase K (NGS grade) / Unkown
HY-NP002 BSA Standard Solution (5 mg/mL) / Unkown
HY-Y0316B Sodium dodecyl sulfate for electrophoresis 99.96% Unkown
HY-108717A Recombinant Proteinase K (DNase & RNase free, animal free) / Unkown
HY-119271 CMLD010509 99.11% Unkown
HY-D1590 BODIPY Green 8-P2M 99.21% Unkown
HY-W284558 Sodium hexadecyl sulfate 98.45% Unkown
HY-Y0700 Calconcarboxylic acid / Unkown
HY-106969A ZD 9379 sodium Antagonist / Unkown
HY-RS12463 SBDS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12599 SDS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W284558S Sodium hexadecyl sulfate-d33 / Unkown
HY-119271A (-)-CMLD010509 / Unkown
HY-RS16499 Sds Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18499 Sbds Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22929 Sds Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Y0316BR Sodium dodecyl sulfate (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SDS VGNC VGNC:80482
Rattus norvegicus SDS RGD RGD:67376
Bos taurus SDS VGNC VGNC:34399
Mus musculus SDS MGD MGI:98270
Macaca mulatta SDS VGNC VGNC:77148
Others SDS NCBI