Cbs - cystathionine beta synthase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24250

Summary

Enables cystathionine beta-synthase activity. Involved in several processes, including cellular response to hypoxia; hydrogen sulfide biosynthetic process; and transsulfuration. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Biomarker of hyperhomocysteinemia and vitamin B12 deficiency. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Apr 2022]

Cbs Products (1)

mRNA Protein Name
NM_012522.2 NP_036654.2 cystathionine beta-synthase

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
20149843 RGD
involved in hydrogen sulfide biosynthetic process IDA
IDA: Inferred from direct assay
20149843 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
20149843 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19352060 RGD
involved in transsulfuration IDA
IDA: Inferred from direct assay
16636197 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystathionine beta-synthase

  • beta-thionase

  • hemoprotein H-450

  • serine sulfhydrase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-Y0337 L-Cysteine 99.3% Yes
HY-W016715 L-Cysteine hydrochloride hydrate Inhibitor 98.0% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-108716 Felezonexor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15300 Skepinone-L Inhibitor 99.79% Unkown
HY-W010062 4-Chlorophenylacetic acid 99.97% Unkown
HY-12852 Diclosulam Inhibitor 98.20% Unkown
HY-131059 CBS1117 Inhibitor 99.76% Unkown
HY-RS02007 CBS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177767 EY-CBS 99.92% Unkown
HY-101556 Namirotene 99.33% Unkown
HY-121841 Cannabidiorcol Inhibitor / Unkown
HY-179433 PROTAC AR Degrader-12 / Unkown
HY-111164 CBS-3595 Inhibitor / Unkown
HY-163523 PYRIB-SO 2 Inhibitor / Unkown
HY-178466 Tubulin polymerization/P-gp-IN-1 / Unkown
HY-182579 CBS-3408 Inhibitor / Unkown
HY-P5343 p53 CBS / Unkown
HY-105983A CBS-1114 hydrochloride Inhibitor / Unkown
HY-RS17100 Cbs Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23544 Cbs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbs NCBI NCBI:875
Mus musculus Cbs NCBI NCBI:12411