Cat. No.: HY-N8518

Malabaricone C

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC₅₀ values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells.

For research use only. We do not sell to patients.

Purity: 99.46%
CAS No.: 63335-25-1
Formula: C₂₁H₂₆O₅
Molecular Weight:358.43

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Malabaricone C Chemical Structure

CAS No.: 63335-25-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Phospholipase Isoforms :

All p38 MAPK Isoforms :

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	5.26 μM Compound: Mal C	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 20805034]
MEF	IC₅₀	11 μM Compound: 3	Inhibition of SMS2 in MEF cells using C6-NBD-ceramide as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by HPLC analysis Inhibition of SMS2 in MEF cells using C6-NBD-ceramide as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by HPLC analysis	[PMID: 31413799]
MEF	IC₅₀	13 μM Compound: 3	Inhibition of SMS1 in MEF cells using C6-NBD-ceramide as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by HPLC analysis Inhibition of SMS1 in MEF cells using C6-NBD-ceramide as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by HPLC analysis	[PMID: 31413799]
RAW264.7	IC₅₀	2.3 μM Compound: 5, Malabaricone C	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method	[PMID: 21978676]

In Vitro

Malabaricone C (0.01-1 mM, 3 h) has little cytotoxic activity against wild-type mouse embryonic fibroblasts cells, MEF^[1].
Malabaricone C (0.01-1 mM, 3 h) decreases the levels of intracellular triglycerides and decreases lipid accumulation in HepG2 cells^[1].
Malabaricone C (1-10 μM, 2 h) inhibits T-cell activation, proliferation, and cytokine production^[2].
Malabaricone C (10 μM, 1 h or 24 h) suppresses mitogen-induced activation of cell surface markers, MAPK and NF-κB in lymphocytes^[2].
Malabaricone C (4-10 μ M, 24 h) induces apoptosis in MCF-7 cells^[3].
Malabaricone C (0-6 μ M, 9 min) increases intracellular Ca²⁺ levels and activates calpain in MCF-7 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Mouse embryonic fibroblasts cells
Concentration:

0.01-1 mM
Incubation Time:

3 h
Result:

Induced 56−97% of the cells viable after 3 h of treatment at concentration levels of 1-0.01 mM in MEFs.

Immunofluorescence^[1]

Cell Line:

HepG2 cells
Concentration:

0.01-1 mM
Incubation Time:

3 h
Result:

Significantly decreased the levels of intracellular triglycerides in a dose-dependent manner while it exhibited no significant changes in the free fatty acids levels, decreased lipid accumulation in a dose-dependent manner.

Cell Proliferation Assay^[2]

Cell Line:

Lymphocytes
Concentration:

1-10 μM
Incubation Time:

2 h
Result:

Inhibited the proliferation of αCD3/ αCD28-activated T-cells and suppressed the secretion of IL-2 and IFN-γ.

Apoptosis Analysis^[3]

Cell Line:

MCF-7 cells
Concentration:

4-10 μM
Incubation Time:

24 h
Result:

Showed condensed nuclei and showed significantly increased (up to 64%, p < 0.001) sub G1 population in MCF-7 cells.

In Vivo

Malabaricone C (High-fat diet supplemented with 0.1%, p.o., daily for 8 weeks) reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver in high fat diet-induced obesity mice models^[1].
Malabaricone C (10 mg/kg, i.p., a single dose for 24 h) inhibits T-cell activation and cytokine secretion in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

High fat diet-induced obesity mice models^[1]
Dosage:

High-fat diet supplemented with 0.1%
Administration:

p.o., daily for 8 weeks
Result:

Reduced weight gain, improved glucose tolerance, and reduced hepatic steatosis in high fat diet-induced obesity mice models.

Animal Model:

Swiss, BALB/c, and C57BL/6 male mice^[2]
Dosage:

10 mg/kg
Administration:

i.p., a single dose for 24 h
Result:

Significantly decreased the percentage of proliferating cells as compared with vehicle control and resulted in significant decrease in mitogen-induced cytokine (IL-2, IFN-γ, and IL-6) secretion by T-cells.

Chemical Information

CAS No. 63335-25-1
Appearance Solid
Molecular Weight 358.43
Formula C₂₁H₂₆O₅
Color White to light yellow
SMILES

O=C(C1=C(O)C=CC=C1O)CCCCCCCCC2=CC=C(O)C(O)=C2
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (3)

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Journal Impact Factor

Adv Sci (Weinh)

Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice. [Abstract]

2025 Jul 28:e15311. PMID: 40719020
Oncogene

TMSB4Y restrains sphingomyelin synthesis via de novo purine synthesis to exert a tumor suppressor function in male esophageal squamous cell carcinoma. [Abstract]

2024 Dec;43(50):3660-3672. PMID: 39443723
SSRN

2025 Aug 13.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (278.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7899 mL

13.9497 mL

27.8995 mL

5 mM

0.5580 mL

2.7899 mL

5.5799 mL

10 mM

0.2790 mL

1.3950 mL

2.7899 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Othman MA, et al. Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett. 2019;10(8):1154-1158. Published 2019 Jul 3. [Content Brief]

[2]. Patwardhan RS, et al. Malabaricone C, a constituent of spice Myristica malabarica, exhibits anti-inflammatory effects via modulation of cellular redox. J Biosci. 2023;48(2):9. [Content Brief]

[3]. Tyagi M, et al. Mechanism of the malabaricone C-induced toxicity to the MCF-7 cell line. Free Radic Res. 2014 Apr;48(4):466-77. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7899 mL	13.9497 mL	27.8995 mL	69.7486 mL
	5 mM	0.5580 mL	2.7899 mL	5.5799 mL	13.9497 mL
	10 mM	0.2790 mL	1.3950 mL	2.7899 mL	6.9749 mL
	15 mM	0.1860 mL	0.9300 mL	1.8600 mL	4.6499 mL
	20 mM	0.1395 mL	0.6975 mL	1.3950 mL	3.4874 mL
	25 mM	0.1116 mL	0.5580 mL	1.1160 mL	2.7899 mL
	30 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3250 mL
	40 mM	0.0697 mL	0.3487 mL	0.6975 mL	1.7437 mL
	50 mM	0.0558 mL	0.2790 mL	0.5580 mL	1.3950 mL
	60 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	80 mM	0.0349 mL	0.1744 mL	0.3487 mL	0.8719 mL
	100 mM	0.0279 mL	0.1395 mL	0.2790 mL	0.6975 mL

Keywords

Malabaricone C

3 Cited Publications

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Malabaricone C

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Publications Citing Use of MedChemExpress (MCE) Malabaricone C

All Phospholipase Isoforms

All p38 MAPK Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Malabaricone C Related Classifications