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MK-4166

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Based on 1 Customer Validation

MK-4166 is a humanized IgG1 agonist anti-human GITR monoclonal antibody. MK-4166 triggers the downstream NF-κB signaling pathway through activation of GITR, and downregulates FOXP3 expression in tumor-infiltrating Tregs, thereby attenuating the immunosuppressive microenvironment and promoting T cell activation. MK-4166 can be used for research on various solid tumors.

For research use only. We do not sell to patients.

  • Purity : 98.20%
  • Molecular Weight:145.2 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for MK-4166
  • Experimental Validation Results for MK-4166
  • MK-4166 Chemical Structure
    MK-4166 Chemical Structure
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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MK-4166 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All TNF Receptor Isoforms

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All NF-κB Isoforms

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Assay Types
  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells with MK-4166 (HY-P991179, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human GITR/TNFRSF18 Protein, His Tag can bind MK-4166. The EC50 for this effect is 85.95 ng/mL.

  • MK-4166 Chemical Structure
    1/16
  • MK-4166
  • Flow cytometric analysis of 1X106 Jurkat cells with MK-4166 (HY-P991179, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human GITR/TNFRSF18 Protein, His Tag can bind MK-4166. The EC50 for this effect is 85.95 ng/mL.