YTHDC1-IN-1
Based on 1 Customer Validation
YTHDC1-IN-1 is a selective YTHDC1 inhibitor with a Kd of 49 nM and an IC50 of 0.35 μM. YTHDC1-IN-1 can inhibit the proliferation and induce apoptosis of acute myeloid leukemia cell lines. YTHDC1-IN-1 has anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 2995344-53-9
- Formula: C13H11Cl2N5
- Molecular Weight:308.17
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Epigenetics Compound Library
HY-L005
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Blood Cancer Compound Library
HY-L079
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
All DNA/RNA Synthesis Isoforms
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Biological Activity
YTHDC1-IN-1 (Compound 40) (1-100 μM; 24-72 h) exhibits antiproliferative activity against acute myeloid leukemia cell lines (with GI50 value of 3.2 μM for THP-1 and IC50 values of 5.6 μM and 8.2 μM for MOLM-13 and NOMO-1, respectively), and can induce apoptosis in THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 cells
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Concentration:12.5, 5 and 10 μM
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Incubation Time:24 h
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Result:Increased the level of cleaved PARP.
Chemical Information
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CAS No. 2995344-53-9
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Appearance Solid
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Molecular Weight 308.17
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Formula C13H11Cl2N5
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Color White to off-white
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SMILES
CNC1=NC(Cl)=NC2=C(CC3=CC=CC(Cl)=C3)NN=C21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (81.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2450 mL | 16.2248 mL | 32.4496 mL | 81.1241 mL |
| 5 mM | 0.6490 mL | 3.2450 mL | 6.4899 mL | 16.2248 mL | |
| 10 mM | 0.3245 mL | 1.6225 mL | 3.2450 mL | 8.1124 mL | |
| 15 mM | 0.2163 mL | 1.0817 mL | 2.1633 mL | 5.4083 mL | |
| 20 mM | 0.1622 mL | 0.8112 mL | 1.6225 mL | 4.0562 mL | |
| 25 mM | 0.1298 mL | 0.6490 mL | 1.2980 mL | 3.2450 mL | |
| 30 mM | 0.1082 mL | 0.5408 mL | 1.0817 mL | 2.7041 mL | |
| 40 mM | 0.0811 mL | 0.4056 mL | 0.8112 mL | 2.0281 mL | |
| 50 mM | 0.0649 mL | 0.3245 mL | 0.6490 mL | 1.6225 mL | |
| 60 mM | 0.0541 mL | 0.2704 mL | 0.5408 mL | 1.3521 mL | |
| 80 mM | 0.0406 mL | 0.2028 mL | 0.4056 mL | 1.0141 mL |
YTHDC1-IN-1 Related Classifications
HY-158974 Related Classifications
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