Cat. No.: HY-101037

Sarcosine

(Synonyms: N-Methylglycine; Sarcosin)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 107-97-1
Formula: C₃H₇NO₂
Molecular Weight:89.09

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Sarcosine Chemical Structure

CAS No.: 107-97-1

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

GlyT1

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All GlyT Isoforms :

GlyT1
GlyT2

In Vivo

Sarcosine (400-800mg/kg; i.p.) significantly raises the threshold for electroconvulsions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Albino Swiss mice weighing (25-30 g)^[2]
Dosage:

100 mg/kg, 200 mg/kg, 400 mg/kg, 800 mg/kg
Administration:

Intraperitoneal injection
Result:

Elevated the seizure threshold at doses of 400 mg/kg and 800 mg/kg in the MEST test in mice.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 107-97-1
Appearance Solid
Molecular Weight 89.09
Formula C₃H₇NO₂
Color White to off-white
SMILES

O=C(O)CNC
Synonyms

N-Methylglycine; Sarcosin
Structure Classification
- Amino acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

All

Sort by:

Journal Impact Factor

Cell Stem Cell

Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury. [Abstract]

2024 Aug 21:S1934-5909(24)00285-6. PMID: 39181130
Gut Microbes

A 4-guanidinobutanoic acid-SLC36A1 axis drives a microbiota‒host feedback loop to regulate intestinal homeostasis. [Abstract]

2026 Dec 31;18(1):2639216. PMID: 41782409
Adv Sci (Weinh)

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2-NETs-Mediated Liver-Bile Barrier Damage. [Abstract]

2026 Apr;13(24):e19500. PMID: 41698066

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (1122.46 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

11.2246 mL

56.1230 mL

112.2460 mL

5 mM

2.2449 mL

11.2246 mL

22.4492 mL

10 mM

1.1225 mL

5.6123 mL

11.2246 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (1122.46 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7. [Content Brief]

[2]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	11.2246 mL	56.1230 mL	112.2460 mL	280.6151 mL
	5 mM	2.2449 mL	11.2246 mL	22.4492 mL	56.1230 mL
	10 mM	1.1225 mL	5.6123 mL	11.2246 mL	28.0615 mL
	15 mM	0.7483 mL	3.7415 mL	7.4831 mL	18.7077 mL
	20 mM	0.5612 mL	2.8062 mL	5.6123 mL	14.0308 mL
	25 mM	0.4490 mL	2.2449 mL	4.4898 mL	11.2246 mL
	30 mM	0.3742 mL	1.8708 mL	3.7415 mL	9.3538 mL
	40 mM	0.2806 mL	1.4031 mL	2.8062 mL	7.0154 mL
	50 mM	0.2245 mL	1.1225 mL	2.2449 mL	5.6123 mL
	60 mM	0.1871 mL	0.9354 mL	1.8708 mL	4.6769 mL
	80 mM	0.1403 mL	0.7015 mL	1.4031 mL	3.5077 mL
	100 mM	0.1122 mL	0.5612 mL	1.1225 mL	2.8062 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Sarcosine

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Neuronal Signaling Compound Library

Natural Product Library

Clinical Compound Library

Human Endogenous Metabolite Compound Library

Drug Repurposing Compound Library

Anti-COVID-19 Compound Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Gut Microbial Metabolite Library

Microbial Metabolite Library

Targeted Diversity Library

Rare Diseases Drug Library

Human Metabolite Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Animal-Sourced Natural Product Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Mouse Metabolite Compound Library

Cosmetic Ingredient Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Amino Acid Metabolite Compound Library

Chinese Baijiu Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Sarcosine

All Endogenous Metabolite Isoforms

All GlyT Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Sarcosine Related Classifications

HY-101037 Related Classifications