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Vorinostat

(Synonyms: SAHA; Suberoylanilide hydroxamic acid)
166 Cited Publications
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Based on 166 publication(s) in Google Scholar

Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.

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  • Pureza: 99.96%
  • No. CAS: 149647-78-9
  • Fòrmula: C14H20N2O3
  • Peso molecular:264.32
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Vorinostat Chemical Structure
    Vorinostat Chemical Structure
  • Experimental Validation Results for Vorinostat
  • Experimental Validation Results for Vorinostat
  • Experimental Validation Results for Vorinostat
  • Experimental Validation Results for Vorinostat
  • Experimental Validation Results for Vorinostat
  • Experimental Validation Results for Vorinostat
  • Experimental Validation Results for Vorinostat
  • Experimental Validation Results for Vorinostat
No. CAS: 149647-78-9
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • Vorinostat Chemical Structure
    Vorinostat Chemical Structure
    1/16
  • 1/16

    Vorinostat purchased from MedChemExpress. Usage Cited in: Commun Biol. 2021 Oct 29;4(1):1235. [Abstract]

    Customer Validation
     TNBC model cells (MDA-MB-231 and BT-549) were treated with indicated HDACi (Vorinostat: 10 µM; Panobinostat: 1 µM; Romidepsin: 1 µM; Givinostat: 1 µM) for 24 h and expression of LIFR, p-STAT3(Y705), and STAT3 were determined using Western blotting.

  • 1/16

    Vorinostat purchased from MedChemExpress. Usage Cited in: RSC Adv. 2018 May 11;8(31):17279-17292. [Abstract]

    Customer Validation
     The NH2 cells expressing Tat. All tested cells are treated with SAHA for 24 h. The expression of GFP for tested J-Lat A2 and 2D10 cells is measured by FACS. Whole cell extracts for tested NH1 and NH2 cells are prepared and examined for the luciferase activities.

  • 1/16

    Vorinostat purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 May 18;S1874-9399(18)30028-2. [Abstract]

    Customer Validation
     Jurkat T cells are treated for various times with Vorinostat 1 μM and Chidamide at 0.6 μM. Levels of SALL2 and cleaved PARP are evaluated by Western blot analysis. β-actin is used as a loading control.

  • 1/16

    Vorinostat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2017 Dec 20;8(1):2207. [Abstract]

    Customer Validation
     HCT116 cells are treated with Vorinostat for 24 h, followed by by western blot analysis for the indicated proteins.

  • 1/16

    Vorinostat purchased from MedChemExpress. Usage Cited in: Mol Psychiatry. 2017 May;22(5):711-723. [Abstract]

    Customer Validation
     Oral SAHA administration increases brain plasma membrane calcium ATPase (PMCA) levels, reduces oxidative stress, improves behavioral deficits and prevents neurodegeneration in ASM knockout (ASMko) mice. (a,b) Western blot of hippocampal membrane extracts from wt (a) and ASMko (b) mice orally administered SAHA complexed to HOP-β-CDX (SAHA) or HOP-β-CDX (control), and probed for PMCA and ATP6V1A.

  • 1/16

    Vorinostat purchased from MedChemExpress. Usage Cited in: Biol Pharm Bull. 2017;40(10):1747-1753. [Abstract]

    Customer Validation
     Synergistic Decrease Bcl-2 Expression by the Combination of Vorinostat with BMS-354825 in MCF-7 Cells.

  • 1/16

    Vorinostat purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 May 23;8(21):34362-34373. [Abstract]

    Customer Validation
     Notch3 protein levels after treatment with SAHA at different concentrations or DMSO (vehicle control), determined by western blot.

  • 1/16

    Vorinostat purchased from MedChemExpress. Usage Cited in: Universidad Autónoma de Madrid. 2015 Jun 15.

    Customer Validation
     SAHA, a histone deacetylase inhibitor that is shown to increase PMCA levels and to enhance calcium clearance in a breast cancer cell model.

  • Vorinostat