dTAG-47
Based on 1 publication(s) in Google Scholar
dTAG-47 is a FKBP12(F36V) PROTAC degrader. dTAG-47 efficiently degrades FKBP12(F36V)-MELK(sg3R) in MELK?/? MDA-MB-468-FKBP12(F36V)-MELK(sg3R) cells. dTAG-47 can be used for the research of basal-like breast cancers (BBC).
(Pink: FKBP12 ligand (HY-114420); Blue: Cereblon ligand (HY-W087383); Black: linker (HY-42773)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.23%
- No. CAS: 2265886-81-3
- Fòrmula: C59H73N5O14
- Peso molecular:1076.24
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Almacenamiento:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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HY-L004
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HY-L074
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Heterocyclic Compound Library
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PROTAC Library
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Publications Citing Use of MedChemExpress (MCE) dTAG-47
MoreVer todos los productos específicos de isoformas PROTACs
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Actividad biológica
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FKBP12 |
Cereblon |
dTAG-47 (500 nM, 14-72 h) efficiently depletes FKBP12F36V-MELK(sg3R) protein in MELK⁻/⁻ MDA-MB-468-FKBP12F36V-MELK(sg3R) cells[1].
dTAG-47 (500 nM, 9 days) does not impair the growth of MELK⁻/⁻ MDA-MB-468-FKBP12F36V-MELK(sg3R) cells[1].
dTAG-47 (0-3000 nM, 48 h) degrades NL-FKBP-Cas9 in a dose-dependent manner in HEK293T CRBN +/+ cells[2].
dTAG-47 (1 μM, 72 h) modulates DNA repair outcomes by increasing error-prone repair frequency with prolonged Cas9 lifetime in HEK293T cells transfected with NL-FKBP-Cas9, RBM20 gRNA and ssODN[2].
dTAG-47 (0- 1000 nM, 72 h) reduces both on-target and off-target editing at EMX1 loci in a dose-dependent manner and enhances on-target versus off-target specificity in HEK293T cells transfected with NL-FKBP-Cas9 and EMX1 gRNA[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2265886-81-3
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Appearance Solid
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Peso molecular 1076.24
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Fòrmula C59H73N5O14
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Color Light yellow to green yellow
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SMILES
O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
2025 Nov 30:2025.11.26.690562. PMID: 41394586
Solvente y solubilidad
DMSO : 100 mg/mL (92.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Hai-Tsang Huang, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693. [Content Brief]
[2]. Sreekanth V, et al. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS Cent Sci. 2020 Dec 23;6(12):2228-2237. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9292 mL | 4.6458 mL | 9.2916 mL | 23.2290 mL |
| 5 mM | 0.1858 mL | 0.9292 mL | 1.8583 mL | 4.6458 mL | |
| 10 mM | 0.0929 mL | 0.4646 mL | 0.9292 mL | 2.3229 mL | |
| 15 mM | 0.0619 mL | 0.3097 mL | 0.6194 mL | 1.5486 mL | |
| 20 mM | 0.0465 mL | 0.2323 mL | 0.4646 mL | 1.1615 mL | |
| 25 mM | 0.0372 mL | 0.1858 mL | 0.3717 mL | 0.9292 mL | |
| 30 mM | 0.0310 mL | 0.1549 mL | 0.3097 mL | 0.7743 mL | |
| 40 mM | 0.0232 mL | 0.1161 mL | 0.2323 mL | 0.5807 mL | |
| 50 mM | 0.0186 mL | 0.0929 mL | 0.1858 mL | 0.4646 mL | |
| 60 mM | 0.0155 mL | 0.0774 mL | 0.1549 mL | 0.3872 mL | |
| 80 mM | 0.0116 mL | 0.0581 mL | 0.1161 mL | 0.2904 mL |
dTAG-47 Related Classifications
HY-147098 Related Classifications
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