country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-117365

Copy Link Print Information

MI-1481

MI-1481 is a highly potent inhibitor of the Menin-MLL1 interaction with IC₅₀ of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1887178-64-4
Fòrmula: C₂₉H₃₀F₃N₇O₂S
Peso molecular:597.65

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MI-1481 Chemical Structure

No. CAS: 1887178-64-4

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Epigenetic Reader Domain :

Cellular Effect

Cell Line	Type	Value	Description	References
Bone marrow cell	GI₅₀	>6 μM Compound: (S)-28; MI-1481	Cytotoxicity against mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]
K562	GI₅₀	>6 μM Compound: (S)-28; MI-1481	Cytotoxicity against human K562 cells assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against human K562 cells assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]
MOLM-13	GI₅₀	61 nM Compound: (S)-28; MI-1481	Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]
MV4-11	GI₅₀	36 nM Compound: (S)-28; MI-1481	Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]
U-937	GI₅₀	>6 μM Compound: (S)-28; MI-1481	Cytotoxicity against human U937 cells assessed as cell growth inhibition after 7 days by MTT assay Cytotoxicity against human U937 cells assessed as cell growth inhibition after 7 days by MTT assay	[PMID: 29738674]

Chemical Information

No. CAS 1887178-64-4
Peso molecular 597.65
Fòrmula C₂₉H₃₀F₃N₇O₂S
SMILES

N#CC(N1C[C@@H](OC2)CNC2=O)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Borkin D, et.al. Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. J Med Chem. 2018 Jun 14;61(11):4832-4850. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

MI-1481

Ver todos los productos específicos de isoformas Epigenetic Reader Domain

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

MI-1481 Related Classifications

HY-117365 Related Classifications