TOP1288
TOP1288 is a narrow spectrum kinase inhibitor for P38α, Src and Syk kinase, with IC50 of 116nM, 24nM and 659nM, respectively. TOP1288 inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1630202-02-6
- Fòrmula: C43H49N7O9S
- Peso molecular:839.96
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
IC50: 24 nM (Src), 116 nM (P38α), 659 nM (Syk)
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1630202-02-6
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Peso molecular 839.96
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Fòrmula C43H49N7O9S
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SMILES
O=C(NC1=CC(C(C)(C)C)=CC(NS(=O)(C)=O)=C1OC)NC2=CC=C(C3=C2C=CC=C3)OC4=NC(NC5=CC(C#C)=CC(C(NCCOCCOCCOC)=O)=C5)=NC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TOP1288 Related Classifications
HY-160930 Related Classifications
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