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Cat. No.: HY-W744272

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Estetrol-d₃

Estetrol-d₃ is the deuterium labeled Estetrol (HY-15731). Estetrol, an orally active estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear?estrogen receptor?modulator. Estetrol binds?ERα?as well as?ERβ?(with a fourfold lower affinity). Estetrol increases?eNOS?expression/activity and NO synthesis in endothelial cells. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast. Estetrol can be used in contraception and menopausal hormone research.

For research use only. We do not sell to patients.

Formula: C₁₈H₂₁D₃O₄
Molecular Weight:307.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Estetrol-d₃ Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NO Synthase Isoforms :

All Endogenous Metabolite Isoforms :

All Estrogen Receptor/ERR Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 15183-37-6
Molecular Weight 307.40
Formula C₁₈H₂₁D₃O₄
SMILES

O[C@@]1([C@]2(CC[C@]3([C@@]([H])(CCC4=C(C(O)=C(C=C43)[2H])[2H])[C@@]2([C@H]([C@H]1O)O)[H])[H])C)[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.