JNUTS013
JNUTS013 is a NLRP3 inflammasome inhibitor. JNUTS013 promotes proteasome-dependent degradation of NLRP3 and inhibits the release of downstream cytokines. JNUTS013 downregulates the expression of inflammation-related proteins including iNOS and COX-2. JNUTS013 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases.
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- CAS No.: 2763983-45-3
- Formule: C20H22O6
- Masse moléculaire:358.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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COX-2 |
NLRP3 inflammasome |
JNUTS013 (10 μM; 24 h) inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages, while cells maintain high viability under this condition[1].
JNUTS013 (10 μM; 24 h) inhibits LPS-induced expression of iNOS, COX-2 and NLRP3 proteins in RAW264.7 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophages treated LPS
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Concentration:10 μM
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Incubation Time:24 h
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Result:Downregulated the expression of LPS-induced iNOS, COX-2, and NLRP3 proteins in RAW264.7 macrophages.
Chemical Information
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CAS No. 2763983-45-3
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Masse moléculaire 358.39
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Formule C20H22O6
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SMILES
OC1=C(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)C=C(C)C(O)=C1C
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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