Nitidanin
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection.
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- CAS No.: 171674-89-8
- Formule: C21H24O8
- Masse moléculaire:404.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh7.5.1 | CC50 |
464.4 μM
Compound: 21
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Cytotoxicity against human Huh7.5.1 cells after 72 hrs by ATPlite assay
Cytotoxicity against human Huh7.5.1 cells after 72 hrs by ATPlite assay
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[PMID: 30485098] |
| KB | ED50 |
>99 μM
Compound: 4
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Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
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[PMID: 16562832] |
Nitidanin shows inhibitory effects to D6 and W2 clones of Plasmodium falciparum with IC50 values of 21.2 and 18.4 μM, respectively[1]. Nitidanin shows noncytotoxic effects to human oral epidermoid carcinoma (KB) cells with an EC50 value ＞99 μM[1]. Nitidanin shows low cytotoxic effect to human hepatoma Huh7.5.1 cells with an CC50 value of 464.4 μM[2]. Nitidanin (0-250 μM; 5 hours) shows anti-HCV activity with an IC50 value of 200 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 171674-89-8
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Masse moléculaire 404.41
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Formule C21H24O8
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SMILES
OC[C@@H]1OC2=C(OC)C=C(/C=C/CO)C=C2O[C@H]1C3=CC(OC)=C(O)C(OC)=C3
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Synonyms
(±)-Nitidanin
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ma C, et al. Antimalarial compounds from Grewia bilamellata. J Nat Prod. 2006 Mar;69(3):346-50. [Content Brief]
[2]. Pilkington LI, et al. 1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles. J Nat Prod. 2018 Dec 28;81(12):2630-2637. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nitidanin Related Classifications
HY-120104 Related Classifications
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