Fumaric acid disodium

Name: Fumaric acid disodium
Brand: MedChemExpress
SKU: HY-W015883A
Rating: 5.0 (4 reviews)

Cat. No.: HY-W015883A Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Fumaric acid disodium is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid disodium exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid disodium can be used in the study of pregnancy-induced hypertension.

For research use only. We do not sell to patients.

CAS No. : 17013-01-3

Size	Stock	Quantity
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
500 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Fumaric acid disodium:

Fumaric acid2,3-¹³C₂ disodium In-stock
Fumaric acid-¹³C₂ In-stock
Fumaric acid In-stock
Fumaric acid disodium (Standard) Get quote

4 Publications Citing Use of MCE Fumaric acid disodium

Cell Proliferation/Viability Assay

Cell Imaging/Staining

Bio/Physico-chemical Assay

: Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]; Fumaric acid (12 h). MTT assays were performed to evaluate the effects of different concentrations of GAA and FA pretreatments on the viability of HK2 cells exposed to CDDP.

: Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]; Fumaric acid (50 μM; 12 h). Western blot analysis was performed to assess the impacts of GAA and FA pretreatments on KIM1 protein levels in HK2 cells following exposure to H₂O₂.

: Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]; Fumaric acid (50 μM; 12 h). FIGURETUNEL staining was performed to evaluate the effects of FA pretreatments on the degree of apoptosis in HK2 cells exposed to CDDP.

: Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]; Fumaric acid (50 μM; 12 h). The effects of the FA pretreatments on intracellular GSH levels in HK2 cells exposed to erastin were evaluated.

: Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]; Fumaric acid (50 μM; 12 h). Western blotting was conducted to evaluate the effects of FA pretreatments on the levels of GPX4 in HK2 cells exposed to erastin.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

View All NF-κB Isoform Specific Products:

View All Isoforms

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All p38 MAPK Isoform Specific Products:

View All Isoforms

p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Fumaric acid (50 μM, 24 h) disodium inhibits p38 MAPK-dependent NF-κB signaling pathway and decreases the expression of eotaxin-1 in TNF-α-stimulated fibroblasts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	NIH/3T3
Concentration:	50 μM
Incubation Time:	24 h
Result:	Inhibited p38 MAPK and IκB-a phosphorylation. Attenuated TNF-a-induced NF-κB and decreased the expression of CCR3. Reduced the NF-κB activation induced by TRADD, TRAF2, and MEKK3.

In Vivo

Fumaric acid (10 mL/kg, intravenously injected) disodium is used to treat gestational hypertension by down-regulating the expression of KCNMB1 and TET1^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Gestational hypertension rat model^[3]
Dosage:	10 mL/kg
Administration:	i.v.
Result:	Downregulated the levels of TET1 and KCNMB1.

Molecular Weight

160.04

Formula

C₄H₂Na₂O₄

CAS No.

17013-01-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])/C=C/C(O[Na])=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (624.84 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2484 mL	31.2422 mL	62.4844 mL
5 mM	1.2497 mL	6.2484 mL	12.4969 mL
10 mM	0.6248 mL	3.1242 mL	6.2484 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (245 KB) HNMR (109 KB) MS (151 KB)

Handling Instructions (2659 KB)

References

[1]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8. [Content Brief]

[2]. Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31. [Content Brief]

[3]. Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22(4):1072. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.2484 mL	31.2422 mL	62.4844 mL	156.2110 mL
	5 mM	1.2497 mL	6.2484 mL	12.4969 mL	31.2422 mL
	10 mM	0.6248 mL	3.1242 mL	6.2484 mL	15.6211 mL
	15 mM	0.4166 mL	2.0828 mL	4.1656 mL	10.4141 mL
	20 mM	0.3124 mL	1.5621 mL	3.1242 mL	7.8105 mL
	25 mM	0.2499 mL	1.2497 mL	2.4994 mL	6.2484 mL
	30 mM	0.2083 mL	1.0414 mL	2.0828 mL	5.2070 mL
	40 mM	0.1562 mL	0.7811 mL	1.5621 mL	3.9053 mL
	50 mM	0.1250 mL	0.6248 mL	1.2497 mL	3.1242 mL
	60 mM	0.1041 mL	0.5207 mL	1.0414 mL	2.6035 mL
	80 mM	0.0781 mL	0.3905 mL	0.7811 mL	1.9526 mL
	100 mM	0.0625 mL	0.3124 mL	0.6248 mL	1.5621 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.