AN-3485
Based on 1 publication(s) in Google Scholar
AN-3485 is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 also has certain anti-tumor activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 97.38%
- No. CAS: 1213827-99-6
- Fòrmula: C14H13BClNO3
- Peso molecular:289.52
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) AN-3485
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Actividad biológica
Descripciòn
IC50 & Target
[2]|
TLR2 |
TLR3 |
TLR4 |
TLR5 |
IL-1β |
IL-6 |
In Vitro
AN-3485 (0-72 h) can inhibit the enhanced cell proliferation, migration, and invasion abilities and suppress the NF-κB signaling pathway in H1975 cells treated with PN1-overexpressing exosomes, indicating that it can weaken the promoting effect of PN1 on the malignant phenotypes of lung cancer cells[1].
AN-3485 (0-100 μM; 0-24 h) can inhibit the expression and release of TNF-α, IL-1β, and IL-6 mediated by TLR2, TLR3, TLR4, and TLR5 in PBMCs and isolated monocytes (IC50: 18-580 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AN-3485 (0.1-1 mg; topically applied to the ears; twice) can significantly inhibit PMA (HY-18739)-induced contact dermatitis and Oxazolone (HY-126360)-induced delayed-type hypersensitivity in mice, as well as the production of cytokines such as IL-1β and IL-6[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1J male mice aged 6-7 weeks old treated collagen (HY-NP003)[2]
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Dosage:35 mg/kg
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Administration:Oral administration (p.o.); twice daily for 20 days
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Result:Inhibited the rate of disease progression, and the cumulative disease score increased less compared with the vehicle-treated group.
Alleviated joint inflammation and damage, including synovial inflammation, pannus formation, cartilage damage, and bone resorption.
Chemical Information
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No. CAS 1213827-99-6
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Appearance Solid
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Peso molecular 289.52
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Fòrmula C14H13BClNO3
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Color White to off-white
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SMILES
NCC1=CC(Cl)=C(OC2=CC=C(COB3O)C3=C2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Virol
Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice. [Abstract]2023 Mar 30;97(3):e0000323. PMID: 36877049
Solvente y solubilidad
In Vitro:
DMSO : 5 mg/mL (17.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Chen Y, et al. Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes. Curr Mol Med. 2024 Oct 25. [Content Brief]
[2]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4540 mL | 17.2700 mL | 34.5399 mL | 86.3498 mL |
| 5 mM | 0.6908 mL | 3.4540 mL | 6.9080 mL | 17.2700 mL | |
| 10 mM | 0.3454 mL | 1.7270 mL | 3.4540 mL | 8.6350 mL | |
| 15 mM | 0.2303 mL | 1.1513 mL | 2.3027 mL | 5.7567 mL |
AN-3485 Related Classifications
HY-18325 Related Classifications
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