Benzcyclane
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Benzcyclane (Bencyclane; Benzcyclan) is a vasodilator with serotonin receptor antagonism. Benzcyclane exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane relaxes high K+-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane is applicable to studies related to cerebral vascular circulation.
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- Pureza : 98.51%
- No. CAS: 2179-37-5
- Fòrmula: C19H31NO
- Peso molecular:289.46
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Actividad biológica
Descripciòn
In Vitro
Benzcyclane (0.0001-0.03 mg/mL; 2-3 minutes per concentration, 10-20 minutes for maximum relaxation) potently relaxes high K+-induced contractures in isolated rabbit basilar artery strips with an ED50 of 0.0011 mg/mL, producing faster and more marked relaxation than in mesenteric artery strips[1].
Benzcyclane (~30 minutes for maximum relaxation) relaxes high K+-induced contractures in isolated rabbit superior mesenteric artery strips with an ED50 of 0.0048 mg/mL, showing weaker and slower relaxation than in basilar artery strips[1].
Benzcyclane exerts the strongest antagonistic effect on serotonin-induced contractions in isolated rabbit superior mesenteric artery strips (presumptive pA2 = 7.3), with weaker noncompetitive antagonism of noradrenaline (pD2' = 4.3) and minimal effect on histamine (pD2' = 3.8)[1].
Benzcyclane (0.006 mg/mL, 0.01 mg/mL; 30 minutes for nerve stimulation, 20 minutes for noradrenaline) selectively inhibits 25 Hz sympathetic nerve-induced contractions in isolated rabbit pulmonary artery radial muscle preparations without affecting responses to exogenous noradrenaline[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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No. CAS 2179-37-5
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Appearance Oil
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Peso molecular 289.46
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Fòrmula C19H31NO
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Color Colorless to light yellow
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SMILES
CN(C)CCCOC1(CC2=CC=CC=C2)CCCCCC1
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Synonyms
Bencyclane; Benzcyclan
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (345.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4547 mL | 17.2735 mL | 34.5471 mL | 86.3677 mL |
| 5 mM | 0.6909 mL | 3.4547 mL | 6.9094 mL | 17.2735 mL | |
| 10 mM | 0.3455 mL | 1.7274 mL | 3.4547 mL | 8.6368 mL | |
| 15 mM | 0.2303 mL | 1.1516 mL | 2.3031 mL | 5.7578 mL | |
| 20 mM | 0.1727 mL | 0.8637 mL | 1.7274 mL | 4.3184 mL | |
| 25 mM | 0.1382 mL | 0.6909 mL | 1.3819 mL | 3.4547 mL | |
| 30 mM | 0.1152 mL | 0.5758 mL | 1.1516 mL | 2.8789 mL | |
| 40 mM | 0.0864 mL | 0.4318 mL | 0.8637 mL | 2.1592 mL | |
| 50 mM | 0.0691 mL | 0.3455 mL | 0.6909 mL | 1.7274 mL | |
| 60 mM | 0.0576 mL | 0.2879 mL | 0.5758 mL | 1.4395 mL | |
| 80 mM | 0.0432 mL | 0.2159 mL | 0.4318 mL | 1.0796 mL | |
| 100 mM | 0.0345 mL | 0.1727 mL | 0.3455 mL | 0.8637 mL |
Benzcyclane Related Classifications
HY-U00134 Related Classifications
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