MC-DOXHZN
Based on 5 publication(s) in Google Scholar
MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) is an albumin-binding proagent of Doxorubicin (HY-15142A) (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN can be used to synthesize ADC.
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- No. CAS: 151038-96-9
- Fòrmula: C37H42N4O13
- Peso molecular:750.75
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MC-DOXHZN
MoreVer todos los productos específicos de isoformas ADC Payloads
MoreVer todos los productos específicos de isoformas Topoisomerase
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Actividad biológica
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Daunorubicins/Doxorubicins |
Chemical Information
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No. CAS 151038-96-9
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Peso molecular 750.75
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Fòrmula C37H42N4O13
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SMILES
[H][C@@]1(O[C@H]2C[C@@](/C(CO)=N\NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1
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Synonyms
(E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Int J Pharm
Dual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancer. [Abstract]2016 Oct 15;512(1):1-13. PMID: 27521706 -
Mol Pharm
Albumin Binding Domain Fusing R/K-X-X-R/K Sequence for Enhancing Tumor Delivery of Doxorubicin. [Abstract]2017 Nov 6;14(11):3739-3749. PMID: 28950700 -
Mol Pharm
Acid-Sensitive Peptide-Conjugated Doxorubicin Mediates the Lysosomal Pathway of Apoptosis and Reverses Drug Resistance in Breast Cancer. [Abstract]2015 Jul 6;12(7):2217-28. PMID: 26035464 -
Bioconjug Chem
Microenvironmental Control of MUC1 Aptamer-Guided Acid-Labile Nanoconjugate within Injectable Microporous Hydrogels. [Abstract]2017 Oct 18;28(10):2530-2537. PMID: 28949511 -
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MC-DOXHZN Related Classifications
HY-16261A Related Classifications
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- MC-DOXHZN
- 151038-96-9
- (E/Z)-Aldoxorubicin
- Doxorubicin(6-maleimidocaproyl)hydrazone
- ADC Payloads
- Topoisomerase
- thiol-containing monoclonal antibodies
- L2987 human lung adenocarcinoma cells
- human IgG
- chimeric BR96
- Michael addition reaction
- DTT-thiolated monoclonal antibodies
- human lung adenocarcinoma cells
- lysosomal-mimicking conditions
- chimeric BR96 monoclonal antibody
- monoclonal antibodies
- Inhibitor
- inhibitor
- inhibit