Sulfalene
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Sulfalene (Sulfametopyrazine) is an orally active antimalarial agent. Sulfalene competes with para-aminobenzoic acid in plasmodial and bacterial folic acid synthesis pathways. Sulfalene reduces trachoma-associated pathological changes. Sulfalene can be used for the research of acute falciparum malaria, Schistosoma mansoni infection, trachoma, chronic bronchitis, and bacteriuria in pregnancy.
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- Pureza: 99.73%
- No. CAS: 152-47-6
- Fòrmula: C11H12N4O3S
- Peso molecular:280.30
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Plasmodium |
Sulfalene exhibits antitrachoma activity in yolk sacs of embryonated chicken eggs[3].
Sulfalene has a free, active fraction of 35%-45% in human plasma, representing a higher biologically available portion than Fanasil[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 152-47-6
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Appearance Solid
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Peso molecular 280.30
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Fòrmula C11H12N4O3S
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Color White to off-white
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SMILES
O=S(C1=CC=C(N)C=C1)(NC2=NC=CN=C2OC)=O
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Synonyms
Sulfametopyrazine; AS-18908
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : 100 mg/mL (356.76 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (288 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Martin DC, et al. Treatment of acute falciparum malaria with sulfalene and trimethoprim. JAMA. 1968 Feb 12;203(7):476-80. [Content Brief]
[2]. Obonyo CO, et al. Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial. Lancet Infect Dis. 2010;10(9):603-611. [Content Brief]
[3]. Bietti GB, et al. Further contributions to the intermittent therapy of trachoma with new long-acting sulfonamides. Am J Ophthalmol. 1967 May;63(5):Suppl:1569-73. [Content Brief]
[4]. Darke CS, et al. Sulfametopyrazine in the prophylaxis of exacerbations of chronic bronchitis. Br J Dis Chest. 1972 Oct;66(4):276-83. [Content Brief]
[5]. Reeves DS. Laboratory and clinical studies with sulfametopyrazine as a treatment for bacteriuria in pregnancy. J Antimicrob Chemother. 1975 Jun;1(2):171-86. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5676 mL | 17.8380 mL | 35.6761 mL | 89.1902 mL |
| 5 mM | 0.7135 mL | 3.5676 mL | 7.1352 mL | 17.8380 mL | |
| 10 mM | 0.3568 mL | 1.7838 mL | 3.5676 mL | 8.9190 mL | |
| 15 mM | 0.2378 mL | 1.1892 mL | 2.3784 mL | 5.9460 mL | |
| 20 mM | 0.1784 mL | 0.8919 mL | 1.7838 mL | 4.4595 mL | |
| 25 mM | 0.1427 mL | 0.7135 mL | 1.4270 mL | 3.5676 mL | |
| 30 mM | 0.1189 mL | 0.5946 mL | 1.1892 mL | 2.9730 mL | |
| 40 mM | 0.0892 mL | 0.4460 mL | 0.8919 mL | 2.2298 mL | |
| 50 mM | 0.0714 mL | 0.3568 mL | 0.7135 mL | 1.7838 mL | |
| 60 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4865 mL | |
| 80 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1149 mL | |
| 100 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8919 mL |
Sulfalene Related Classifications
HY-A0130 Related Classifications
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