ADG-2e
ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells.
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- No. CAS: 2419951-75-8
- Fòrmula: C42H67N11O4
- Peso molecular:790.05
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
ADG-2e (1-64 μg/mL, 22 hours) exhibits twice the antibacterial activity compared to other antibiotics in methicillin-resistant S. aureus (MRSA) or multidrug-resistant P. aeruginosa (MDRPA) [1]. ADG-2e (0-60 μg/mL, 2 hours) shows only slight hemolysis with increasing concentration[1]. ADG-2e (0-100 μM, 24 hours) does not inhibit the proliferation of MDA-MB-231 cells but has a role in the migration of cancer cells by inserting into the surface of them and affecting cell motility[1]. ADG-2e (0-40 μM, 6 hours) causes actin reorganization to promote its multiple lamellar structures formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Sheep red blood cells (sRBCs)
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Concentration:0-60 μg/mL
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Incubation Time:2 hours
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Result:Showed any hemolysis until 16 μg/mL and showed slight hemolysis at 32 μg/mL.
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Cell Line:Metastatic breastcancer cell line MDA-MB-231
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Concentration:0-100 μM
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Incubation Time:24 hours
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Result:No significant inhibitory effect on the proliferation of MDA-MB-231 cells.
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Cell Line:Metastatic breastcancer cell line MDA-MB-231
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Concentration:0-40 μM
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Incubation Time:6 hours
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Result:Showed an increase in actin lamellipodium generation.
Chemical Information
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No. CAS 2419951-75-8
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Peso molecular 790.05
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Fòrmula C42H67N11O4
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SMILES
CC1=CN([C@H]2C[C@H](NC(CC34C[C@@H]5C[C@H](C3)C[C@H](C4)C5)=O)[C@@H](CNC(CC67C[C@@H]8C[C@H](C6)C[C@H](C7)C8)=O)O2)C(N=C1N(CCCNC(N)=N)CCCNC(N)=N)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ADG-2e Related Classifications
HY-147522 Related Classifications
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