AMP-PCP
Based on 2 publication(s) in Google Scholar
AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90.
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- No. CAS: 3469-78-1
- Fòrmula: C11H18N5O12P3
- Peso molecular:505.21
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Publications Citing Use of MedChemExpress (MCE) AMP-PCP
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Actividad biológica
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HSP90 3.8 μM (Kd) |
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Cell Line
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Type | Value | Description | References |
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| Oocyte | EC50 |
9200 nM
Compound: beta,gamma-meATP
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The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 3 uM, expressed in Xenopus oocytes
The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 3 uM, expressed in Xenopus oocytes
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[PMID: 12213051] |
AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3469-78-1
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Peso molecular 505.21
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Fòrmula C11H18N5O12P3
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SMILES
O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O)=O)(O)=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling. [Abstract]2025 Oct 29;16(1):9554. PMID: 41162367 -
ACS Nano
Emerging of Ultrafine Membraneless Organelles as the Missing Piece of Nanostress: Mechanism of Biogenesis and Implications at Multilevels. [Abstract]2025 Feb 11;19(5):5659-5679. PMID: 39882824
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMP-PCP Related Classifications
HY-106723 Related Classifications
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